Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach
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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional de Colombia
2012
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| author | Edgar A. Ahumada |
| author_facet | Edgar A. Ahumada |
| contents | Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach Edgar A. Ahumada Daniel R. Delgado Fleming Martínez Química Key words acetaminophen binary mixtures solubility parameter extended Hildebrand solubility approach The Extended Hildebrand Solubility Ap - proach (EHSA) was applied in the pre - sent work to evaluate the solubility of the analgesic drug acetaminophen (paraceta - mol) in polyethylene glycol 400 + wa - ter mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in or - der four (overall deviation below 0.7%), when the W interaction parameter is re - lated to the solubility parameter of the mixtures. Thus, the deviations obtained in the estimated solubility with respect to experimental solubility were lower than those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures’ solubility parameters (close to 1.5%). 2012 artículo científico 0120-2804 https://www.redalyc.org/articulo.oa?id=309031894007 en http://www.redalyc.org/revista.oa?id=3090 Revista Colombiana de Química application/pdf Universidad Nacional de Colombia Revista Colombiana de Química (Colombia) Num.3 Vol.41 |
| format | Artículo científico |
| id | redalyc_309031894007 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach Edgar A. Ahumada Química Key words acetaminophen binary mixtures solubility parameter extended Hildebrand solubility approach Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach Edgar A. Ahumada Daniel R. Delgado Fleming Martínez Química Key words acetaminophen binary mixtures solubility parameter extended Hildebrand solubility approach The Extended Hildebrand Solubility Ap - proach (EHSA) was applied in the pre - sent work to evaluate the solubility of the analgesic drug acetaminophen (paraceta - mol) in polyethylene glycol 400 + wa - ter mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in or - der four (overall deviation below 0.7%), when the W interaction parameter is re - lated to the solubility parameter of the mixtures. Thus, the deviations obtained in the estimated solubility with respect to experimental solubility were lower than those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures’ solubility parameters (close to 1.5%). 2012 artículo científico 0120-2804 https://www.redalyc.org/articulo.oa?id=309031894007 en http://www.redalyc.org/revista.oa?id=3090 Revista Colombiana de Química application/pdf Universidad Nacional de Colombia Revista Colombiana de Química (Colombia) Num.3 Vol.41 |
| title | Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach |
| topic | Química Key words acetaminophen binary mixtures solubility parameter extended Hildebrand solubility approach |
| url | https://www.redalyc.org/articulo.oa?id=309031894007 |