Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
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| Format: | Artículo científico |
| Sprache: | en |
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Universidad Nacional de Colombia
2017
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| _version_ | 1876462971043971072 |
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| author | Melissa Barrera Tomas |
| author_facet | Melissa Barrera Tomas |
| contents | Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity Melissa Barrera Tomas Gloria Eva Tomas Chota Patricia Sheen Cortavarría Patricia Fuentes Bonilla Miguel Angel Inocente Camones Julio Santiago Contreras Química MIC TQMF Evernia prunastri condensation reaction ãompound usnic acid M1A6 isolated from lichen Evernia prunastri Mãajamarca0PeruA and the synthesis and characterization of its acyl0hydrazone M2A6 from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux6 giving an overall yield of SDB6 were evaluatedμ çoth compounds were evaluated and compared with isoniazid according to its anti0 Mycobacterium tuberculosis activity based on the tetrazolium microplate assay MTQMFAμ ãompound 1 had MIã Mminimal inhibitory concentrationA value of H8μL μg/mL in each test of H72Rv Msusceptible typeA6 Tç OM S2 Mresistant wild typeA and MOR OM HLS4 Mmulti drug resistances typeA strainsμ In similar tests6 compound 2 MIã values were 3μL6 8RμL and 8RμL μg/mL respectivelyμ 2017 artículo científico 0120-2804 https://www.redalyc.org/articulo.oa?id=309052302003 https://www.redalyc.org/journal/3090/309052302003/ https://www.redalyc.org/journal/3090/309052302003/html/ https://www.redalyc.org/journal/3090/309052302003/309052302003.epub https://www.redalyc.org/journal/3090/309052302003/movil en http://www.redalyc.org/revista.oa?id=3090 Revista Colombiana de Química application/pdf Universidad Nacional de Colombia Revista Colombiana de Química (Colombia) Num.3 Vol.46 |
| format | Artículo científico |
| id | redalyc_309052302003 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity Melissa Barrera Tomas Química MIC TQMF Evernia prunastri condensation reaction Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity Melissa Barrera Tomas Gloria Eva Tomas Chota Patricia Sheen Cortavarría Patricia Fuentes Bonilla Miguel Angel Inocente Camones Julio Santiago Contreras Química MIC TQMF Evernia prunastri condensation reaction ãompound usnic acid M1A6 isolated from lichen Evernia prunastri Mãajamarca0PeruA and the synthesis and characterization of its acyl0hydrazone M2A6 from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux6 giving an overall yield of SDB6 were evaluatedμ çoth compounds were evaluated and compared with isoniazid according to its anti0 Mycobacterium tuberculosis activity based on the tetrazolium microplate assay MTQMFAμ ãompound 1 had MIã Mminimal inhibitory concentrationA value of H8μL μg/mL in each test of H72Rv Msusceptible typeA6 Tç OM S2 Mresistant wild typeA and MOR OM HLS4 Mmulti drug resistances typeA strainsμ In similar tests6 compound 2 MIã values were 3μL6 8RμL and 8RμL μg/mL respectivelyμ 2017 artículo científico 0120-2804 https://www.redalyc.org/articulo.oa?id=309052302003 https://www.redalyc.org/journal/3090/309052302003/ https://www.redalyc.org/journal/3090/309052302003/html/ https://www.redalyc.org/journal/3090/309052302003/309052302003.epub https://www.redalyc.org/journal/3090/309052302003/movil en http://www.redalyc.org/revista.oa?id=3090 Revista Colombiana de Química application/pdf Universidad Nacional de Colombia Revista Colombiana de Química (Colombia) Num.3 Vol.46 |
| title | Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity |
| topic | Química MIC TQMF Evernia prunastri condensation reaction |
| url | https://www.redalyc.org/articulo.oa?id=309052302003 https://www.redalyc.org/journal/3090/309052302003/ https://www.redalyc.org/journal/3090/309052302003/html/ https://www.redalyc.org/journal/3090/309052302003/309052302003.epub https://www.redalyc.org/journal/3090/309052302003/movil |