Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Associação de Psiquiatria do Rio Grande do Sul
2017
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| _version_ | 1876460396259311616 |
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| author | Maiko A. Schneider |
| author_facet | Maiko A. Schneider |
| contents | Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery Maiko A. Schneider Tahiana Andreazza Anna Martha V. Fontanari Angelo B. Costa Dhiordan C. da Silva Bianca W. de Aguiar Raffael Massuda Mariana Pedrini Clarissa S. Gama Karine Schwarz Marcia Kauer-Sant’Anna Maria Ines R. Lobato Psicología BDNF Transsexualism sex reassignment surgery Introduction: Transsexualism (ICD-10) is a condition characte-rized by a strong and persistent dissociation with one’s assigned gender. Sex reassignment surgery (SRS) and hormone therapy provide a means of allowing transsexual individuals to feel more congruent with their gender and have played a major role in treatment over the past 70 years. Brain-derived neurotrophic factor (BDNF) appears to play a key role in recovery from acute surgical trauma and environmentally mediated vulnerability to psychopathology. We hypothesize that BDNF may be a biomarker of alleviation of gender incongruence suffering.Objectives: To measure preoperative and postoperative serum BDNF levels in transsexual individuals as a biomarker of allevia-tion of stress related to gender incongruence after SRS.Methods: Thirty-two male-to-female transsexual people who underwent both surgery and hormonal treatment were selected from our initial sample. BDNF serum levels were assessed befo-re and after SRS with sandwich enzyme linked immunosorbent assay (ELISA). The time elapsed between the pre-SRS and post--SRS blood collections was also measured.Results: No significant difference was found in pre-SRS or post--SRS BDNF levels or with relation to the time elapsed after SRS when BDNF levels were measured.Conclusion: Alleviation of the suffering related to gender in-congruence after SRS cannot be assessed by BDNF alone. Sur-gical solutions may not provide a quick fix for psychological dis-tress associated with transsexualism and SRS may serve as one step toward, rather than as the conclusion of, construction of a person’s gender identity. 2017 artículo científico 2237-6089 https://www.redalyc.org/articulo.oa?id=311050433006 en http://www.redalyc.org/revista.oa?id=3110 Trends in Psychiatry and Psychotherapy application/pdf Associação de Psiquiatria do Rio Grande do Sul Trends in Psychiatry and Psychotherapy (Brasil) Num.1 Vol.39 |
| format | Artículo científico |
| id | redalyc_311050433006 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Associação de Psiquiatria do Rio Grande do Sul |
| spellingShingle | Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery Maiko A. Schneider Psicología BDNF Transsexualism sex reassignment surgery Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery Maiko A. Schneider Tahiana Andreazza Anna Martha V. Fontanari Angelo B. Costa Dhiordan C. da Silva Bianca W. de Aguiar Raffael Massuda Mariana Pedrini Clarissa S. Gama Karine Schwarz Marcia Kauer-Sant’Anna Maria Ines R. Lobato Psicología BDNF Transsexualism sex reassignment surgery Introduction: Transsexualism (ICD-10) is a condition characte-rized by a strong and persistent dissociation with one’s assigned gender. Sex reassignment surgery (SRS) and hormone therapy provide a means of allowing transsexual individuals to feel more congruent with their gender and have played a major role in treatment over the past 70 years. Brain-derived neurotrophic factor (BDNF) appears to play a key role in recovery from acute surgical trauma and environmentally mediated vulnerability to psychopathology. We hypothesize that BDNF may be a biomarker of alleviation of gender incongruence suffering.Objectives: To measure preoperative and postoperative serum BDNF levels in transsexual individuals as a biomarker of allevia-tion of stress related to gender incongruence after SRS.Methods: Thirty-two male-to-female transsexual people who underwent both surgery and hormonal treatment were selected from our initial sample. BDNF serum levels were assessed befo-re and after SRS with sandwich enzyme linked immunosorbent assay (ELISA). The time elapsed between the pre-SRS and post--SRS blood collections was also measured.Results: No significant difference was found in pre-SRS or post--SRS BDNF levels or with relation to the time elapsed after SRS when BDNF levels were measured.Conclusion: Alleviation of the suffering related to gender in-congruence after SRS cannot be assessed by BDNF alone. Sur-gical solutions may not provide a quick fix for psychological dis-tress associated with transsexualism and SRS may serve as one step toward, rather than as the conclusion of, construction of a person’s gender identity. 2017 artículo científico 2237-6089 https://www.redalyc.org/articulo.oa?id=311050433006 en http://www.redalyc.org/revista.oa?id=3110 Trends in Psychiatry and Psychotherapy application/pdf Associação de Psiquiatria do Rio Grande do Sul Trends in Psychiatry and Psychotherapy (Brasil) Num.1 Vol.39 |
| title | Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery |
| topic | Psicología BDNF Transsexualism sex reassignment surgery |
| url | https://www.redalyc.org/articulo.oa?id=311050433006 |