Evaluation of the effect of coca leaf powder consumption on bone turnover in postmenopausal women
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Peruana de Obstetricia y Ginecología
2017
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| _version_ | 1876449410051735552 |
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| author | Kusy Trigo-Pérez |
| author_facet | Kusy Trigo-Pérez |
| contents | Evaluation of the effect of coca leaf powder consumption on bone turnover in postmenopausal women Kusy Trigo-Pérez Silvia Suárez-Cunza Medicina Bone turnover Erythroxylum coca Antioxidant capacity Introduction: Every year, about 25 million women all over the world experience menopause. Nearly 30% of them will suffer from osteoporosis. Conventional treatments tend to have side effects. In Peru, we have Erythroxylum coca , a vegetal alternative high in calcium, fiber and polyphenols. Objectives: To test the effects of the consumption of coca leaf powder in postmenopausal women and analyze the antioxidant capacity of coca leaf powder. Design: Quantitative, quasi-experimental, pre-test post-test study. Institution: Centro de Investigación de Bioquímica y Nutrición, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participants: Volunteer postmenopausal women. Methodology: Unique and self-controlled treatment of 25 volunteers who met inclusion and exclusion criteria. Twenty one completed the treatment, which consisted of the daily ingestion of 4 g of coca leaf powder mixed with water for a period of 90 days. They kept their regular diet and lifestyle. Three blood samples per volunteer were taken before, after 45 and 90 days of treatment. Main outcomes: We measured procollagen 1 N-terminal propeptide (P1NP), N-telopeptide of type 1 collagen (NTX1), beta-crosslaps (βCTX) and human bone alkaline phosphatase (BALP) in the volunteers. TEAC-ABTS (Trolox equivalent antioxidant capacity), FRAP (Ferric reducing antioxidant power) and polyphenols were determined in coca leaf powder. Results: A significant decrease in the bone resorption indicator NTX1 (from 12.719 to 0.9945 ng/mL; p<0.05) was found. The bone formation indicator P1NP had a positive median difference. Coca leaf powder showed antioxidant capacity (TEAC-ABTS of 2.74 μmol/mL, FRAP of 73.60 mg AAE/g); the content of polyphenols was 3 089.34 mg AG/100 g. These results show coca leaf powder could potentially benefit bone metabolism. Conclusion: The incorporation of coca leaf powder into the regular diet for a period of 90 days generated a change in the indicators of bone density in women. 2017 artículo científico 2304-5124 https://www.redalyc.org/articulo.oa?id=323454392002 en http://www.redalyc.org/revista.oa?id=3234 Revista Peruana de Ginecología y Obstetricia application/pdf Sociedad Peruana de Obstetricia y Ginecología Revista Peruana de Ginecología y Obstetricia (Perú) Num.4 Vol.63 |
| format | Artículo científico |
| id | redalyc_323454392002 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Sociedad Peruana de Obstetricia y Ginecología |
| spellingShingle | Evaluation of the effect of coca leaf powder consumption on bone turnover in postmenopausal women Kusy Trigo-Pérez Medicina Bone turnover Erythroxylum coca Antioxidant capacity Evaluation of the effect of coca leaf powder consumption on bone turnover in postmenopausal women Kusy Trigo-Pérez Silvia Suárez-Cunza Medicina Bone turnover Erythroxylum coca Antioxidant capacity Introduction: Every year, about 25 million women all over the world experience menopause. Nearly 30% of them will suffer from osteoporosis. Conventional treatments tend to have side effects. In Peru, we have Erythroxylum coca , a vegetal alternative high in calcium, fiber and polyphenols. Objectives: To test the effects of the consumption of coca leaf powder in postmenopausal women and analyze the antioxidant capacity of coca leaf powder. Design: Quantitative, quasi-experimental, pre-test post-test study. Institution: Centro de Investigación de Bioquímica y Nutrición, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participants: Volunteer postmenopausal women. Methodology: Unique and self-controlled treatment of 25 volunteers who met inclusion and exclusion criteria. Twenty one completed the treatment, which consisted of the daily ingestion of 4 g of coca leaf powder mixed with water for a period of 90 days. They kept their regular diet and lifestyle. Three blood samples per volunteer were taken before, after 45 and 90 days of treatment. Main outcomes: We measured procollagen 1 N-terminal propeptide (P1NP), N-telopeptide of type 1 collagen (NTX1), beta-crosslaps (βCTX) and human bone alkaline phosphatase (BALP) in the volunteers. TEAC-ABTS (Trolox equivalent antioxidant capacity), FRAP (Ferric reducing antioxidant power) and polyphenols were determined in coca leaf powder. Results: A significant decrease in the bone resorption indicator NTX1 (from 12.719 to 0.9945 ng/mL; p<0.05) was found. The bone formation indicator P1NP had a positive median difference. Coca leaf powder showed antioxidant capacity (TEAC-ABTS of 2.74 μmol/mL, FRAP of 73.60 mg AAE/g); the content of polyphenols was 3 089.34 mg AG/100 g. These results show coca leaf powder could potentially benefit bone metabolism. Conclusion: The incorporation of coca leaf powder into the regular diet for a period of 90 days generated a change in the indicators of bone density in women. 2017 artículo científico 2304-5124 https://www.redalyc.org/articulo.oa?id=323454392002 en http://www.redalyc.org/revista.oa?id=3234 Revista Peruana de Ginecología y Obstetricia application/pdf Sociedad Peruana de Obstetricia y Ginecología Revista Peruana de Ginecología y Obstetricia (Perú) Num.4 Vol.63 |
| title | Evaluation of the effect of coca leaf powder consumption on bone turnover in postmenopausal women |
| topic | Medicina Bone turnover Erythroxylum coca Antioxidant capacity |
| url | https://www.redalyc.org/articulo.oa?id=323454392002 |