The central role of RNA in the genetic programming of complex organisms
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2010
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| _version_ | 1876449361695604736 |
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| author | John S. Mattick |
| author_facet | John S. Mattick |
| contents | The central role of RNA in the genetic programming of complex organisms John S. Mattick Multidisciplinaria (Ciencias Naturales y Exactas) brain epigenome development RNA editing noncoding RNA Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain. 2010 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32717686016 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.82 |
| format | Artículo científico |
| id | redalyc_32717686016 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The central role of RNA in the genetic programming of complex organisms John S. Mattick Multidisciplinaria (Ciencias Naturales y Exactas) brain epigenome development RNA editing noncoding RNA The central role of RNA in the genetic programming of complex organisms John S. Mattick Multidisciplinaria (Ciencias Naturales y Exactas) brain epigenome development RNA editing noncoding RNA Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain. 2010 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32717686016 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.82 |
| title | The central role of RNA in the genetic programming of complex organisms |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) brain epigenome development RNA editing noncoding RNA |
| url | https://www.redalyc.org/articulo.oa?id=32717686016 |