Schistosome serine protease inhibitors: parasite defense or homeostasis?
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| Format: | Artículo científico |
| Sprache: | en |
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Academia Brasileira de Ciências
2011
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| author | LANDYS A. LOPEZ QUEZADA |
| author_facet | LANDYS A. LOPEZ QUEZADA |
| contents | Schistosome serine protease inhibitors: parasite defense or homeostasis? LANDYS A. LOPEZ QUEZADA JAMES H. McKERROW Multidisciplinaria (Ciencias Naturales y Exactas) serpin genome protease inhibitor Schistosomiasis Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic analysis of two major serpin clades. S. mansoni shows a greater multiplicity of serpin genes, perhaps reflecting adaptation to infection of a human host. Putative targets of schistosome serpins can be predicted from the sequence of the reactive center loop (RCL). Schistosome serpins may play important roles in both post-translational regulation of schistosome-derived proteases, as well as parasite defense mechanisms against the action of host proteases. 2011 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32719267021 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.83 |
| format | Artículo científico |
| id | redalyc_32719267021 |
| institution | Redalyc |
| language | en |
| publishDate | 2011 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Schistosome serine protease inhibitors: parasite defense or homeostasis? LANDYS A. LOPEZ QUEZADA Multidisciplinaria (Ciencias Naturales y Exactas) serpin genome protease inhibitor Schistosomiasis Schistosome serine protease inhibitors: parasite defense or homeostasis? LANDYS A. LOPEZ QUEZADA JAMES H. McKERROW Multidisciplinaria (Ciencias Naturales y Exactas) serpin genome protease inhibitor Schistosomiasis Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic analysis of two major serpin clades. S. mansoni shows a greater multiplicity of serpin genes, perhaps reflecting adaptation to infection of a human host. Putative targets of schistosome serpins can be predicted from the sequence of the reactive center loop (RCL). Schistosome serpins may play important roles in both post-translational regulation of schistosome-derived proteases, as well as parasite defense mechanisms against the action of host proteases. 2011 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32719267021 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.83 |
| title | Schistosome serine protease inhibitors: parasite defense or homeostasis? |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) serpin genome protease inhibitor Schistosomiasis |
| url | https://www.redalyc.org/articulo.oa?id=32719267021 |