Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2012
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| _version_ | 1876480942423408640 |
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| author | Carolina R. Silva |
| author_facet | Carolina R. Silva |
| contents | Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice Carolina R. Silva Pabline M. Vieira Suzana C. Santos Lee Chen-Chen Multidisciplinaria (Ciencias Naturales y Exactas) SOS Inductest Cytotoxicity genotoxicity micronucleus test Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as "sofre-do-rim-quem-quer" and "araticum-seco", is a shrub of the Annonaceae family that occurs in several regions of Brazil. In folk medicine the infusion of its leaves and twigs is used to treat rheumatism and renal colic, whereas the seed powder is mixed with water to treat pediculosis. Previous studies have described biological activities of this plant with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial and antiprotozoal effects. In the present work, genotoxicity and cytotoxicity of Duguetia furfuracea lyophilized leaf extract were evaluated using the prophage λ induction test (SOS-Inductest) and mouse bone marrow micronucleus test. Our results showed that Duguetia furfuracea lyophilized leaf extract did not present an increase either in the induction of prophage λ (P>0.05) using the SOS-inductest or in the micronucleated polychromatic erythrocytes (P>0.05) using the micronucleus test, suggesting absence of genotoxicity in both tests. On the other hand, a significant decrease in the number of bacteria, (P<0.05), as well as a significant decrease in the polychromatic erythrocytes and normochromatic erythrocytes ratio, (P<0.05), were observed, showing the cytotoxic action of Duguetia furfuracea lyophilized leaf extract. Thus, Duguetia furfuracea did not present the genotoxic action, but showed a cytotoxic effect in both assays utilized in the present work. 2012 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32721622015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.84 |
| format | Artículo científico |
| id | redalyc_32721622015 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice Carolina R. Silva Multidisciplinaria (Ciencias Naturales y Exactas) SOS Inductest Cytotoxicity genotoxicity micronucleus test Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice Carolina R. Silva Pabline M. Vieira Suzana C. Santos Lee Chen-Chen Multidisciplinaria (Ciencias Naturales y Exactas) SOS Inductest Cytotoxicity genotoxicity micronucleus test Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as "sofre-do-rim-quem-quer" and "araticum-seco", is a shrub of the Annonaceae family that occurs in several regions of Brazil. In folk medicine the infusion of its leaves and twigs is used to treat rheumatism and renal colic, whereas the seed powder is mixed with water to treat pediculosis. Previous studies have described biological activities of this plant with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial and antiprotozoal effects. In the present work, genotoxicity and cytotoxicity of Duguetia furfuracea lyophilized leaf extract were evaluated using the prophage λ induction test (SOS-Inductest) and mouse bone marrow micronucleus test. Our results showed that Duguetia furfuracea lyophilized leaf extract did not present an increase either in the induction of prophage λ (P>0.05) using the SOS-inductest or in the micronucleated polychromatic erythrocytes (P>0.05) using the micronucleus test, suggesting absence of genotoxicity in both tests. On the other hand, a significant decrease in the number of bacteria, (P<0.05), as well as a significant decrease in the polychromatic erythrocytes and normochromatic erythrocytes ratio, (P<0.05), were observed, showing the cytotoxic action of Duguetia furfuracea lyophilized leaf extract. Thus, Duguetia furfuracea did not present the genotoxic action, but showed a cytotoxic effect in both assays utilized in the present work. 2012 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32721622015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.84 |
| title | Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) SOS Inductest Cytotoxicity genotoxicity micronucleus test |
| url | https://www.redalyc.org/articulo.oa?id=32721622015 |