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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2012
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=32723112012 |
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Sommario:
- Treatment of critical defects produced in calvaria of mice with mesenchymal stem cells Betânia S. Monteiro Napoleão M. Argôlo-Neto Nance B. Nardi Pedro C. Chagastelles Pablo H. Carvalho Laila P. Bonfá Richard R. Filgueiras Amanda S. Reis Ricardo J. Del Carlo Multidisciplinaria (Ciencias Naturales y Exactas) Mice Calvaria Bone therapy Autologous graft Mesenchymal stem cell Mesenchymal stem cells (MSC) are present in specialized niches in perivascular regions of adult tissues and are able to differentiate into various cell types, such as those committed to repairing. Bone marrow derived MSC from eight young mice C57BL/ 6 gfp+ were expanded in culture for repairing critical defects in calvarial bone produced in twenty-four young isogenic adult C57BL/6 mice. The animals were subjected to a cranial defect of 6.0mm diameter and divided into two equal experimental groups. Control group did not receive any treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL into the defects. The group treated with MSC showed increased angiogenesis and amount of new bone deposited on the defect limits than that observed in the control group. The results demonstrated that transplantation of bone marrow-derived MSC of C57BL/6 gfp+ mice to bone critical defects produced in mice calvarial contributes positively to the bone repair process. MSC presets ability to influence the correct functioning of osteoblasts, increases the amount of mobilized cells for the repairing process, speeds up growth, and increases deposition of bone matrix. 2012 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32723112012 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.84