DNA damage in children and adolescents with cardiovascular disease risk factors
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2012
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| _version_ | 1876428305857511424 |
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| author | Mariele Kliemann |
| author_facet | Mariele Kliemann |
| contents | DNA damage in children and adolescents with cardiovascular disease risk factors Mariele Kliemann Daniel Prá Luiza L. Müller Liziane Hermes Jorge A. Horta Miriam B. Reckziegel Miria S. Burgos Sharbel W. Maluf Silvia I.R. Franke Juliana da Silva Multidisciplinaria (Ciencias Naturales y Exactas) diet child adolescent Comet assay anthropometry The risk of developing cardiovascular disease (CVD) is related to lifestyle (e.g. diet, physical activity and smoking) as well as to genetic factors. This study aimed at evaluating the association between CVD risk factors and DNA damage levels in children and adolescents. Anthropometry, diet and serum CVD risk factors were evaluated by standard procedures. DNA damage levels were accessed by the comet assay (Single cell gel electrophoresis; SCGE) and cytokinesis-blocked micronucleus (CBMN) assays in leukocytes. A total of 34 children and adolescents selected from a population sample were divided into three groups according to their level of CVD risk. Moderate and high CVD risk subjects showed significantly higher body fat and serum CVD risk markers than low risk subjects (P<0.05). High risk subjects also showed a significant increase in DNA damage, which was higher than that provided by low and moderate risk subjects according to SCGE, but not according to the CBMN assay. Vitamin C intake was inversely correlated with DNA damage by SCGE, and micronucleus (MN) was inversely correlated with folate intake. The present results indicate an increase in DNA damage that may be a consequence of oxidative stress in young individuals with risk factors for CVD, indicating that the DNA damage level can aid in evaluating the risk of CVD. 2012 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32723112015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.84 |
| format | Artículo científico |
| id | redalyc_32723112015 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | DNA damage in children and adolescents with cardiovascular disease risk factors Mariele Kliemann Multidisciplinaria (Ciencias Naturales y Exactas) diet child adolescent Comet assay anthropometry DNA damage in children and adolescents with cardiovascular disease risk factors Mariele Kliemann Daniel Prá Luiza L. Müller Liziane Hermes Jorge A. Horta Miriam B. Reckziegel Miria S. Burgos Sharbel W. Maluf Silvia I.R. Franke Juliana da Silva Multidisciplinaria (Ciencias Naturales y Exactas) diet child adolescent Comet assay anthropometry The risk of developing cardiovascular disease (CVD) is related to lifestyle (e.g. diet, physical activity and smoking) as well as to genetic factors. This study aimed at evaluating the association between CVD risk factors and DNA damage levels in children and adolescents. Anthropometry, diet and serum CVD risk factors were evaluated by standard procedures. DNA damage levels were accessed by the comet assay (Single cell gel electrophoresis; SCGE) and cytokinesis-blocked micronucleus (CBMN) assays in leukocytes. A total of 34 children and adolescents selected from a population sample were divided into three groups according to their level of CVD risk. Moderate and high CVD risk subjects showed significantly higher body fat and serum CVD risk markers than low risk subjects (P<0.05). High risk subjects also showed a significant increase in DNA damage, which was higher than that provided by low and moderate risk subjects according to SCGE, but not according to the CBMN assay. Vitamin C intake was inversely correlated with DNA damage by SCGE, and micronucleus (MN) was inversely correlated with folate intake. The present results indicate an increase in DNA damage that may be a consequence of oxidative stress in young individuals with risk factors for CVD, indicating that the DNA damage level can aid in evaluating the risk of CVD. 2012 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32723112015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.84 |
| title | DNA damage in children and adolescents with cardiovascular disease risk factors |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) diet child adolescent Comet assay anthropometry |
| url | https://www.redalyc.org/articulo.oa?id=32723112015 |