Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
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| Format: | Artículo científico |
| Sprache: | en |
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Academia Brasileira de Ciências
2015
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| author | OLGA M.M.F. OLIVEIRA |
| author_facet | OLGA M.M.F. OLIVEIRA |
| contents | Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system OLGA M.M.F. OLIVEIRA IGUATEMY L. BRUNETTI NAJEH M. KHALIL Multidisciplinaria (Ciencias Naturales y Exactas) low Nicotine vitamin E tryptophan myeloperoxidase In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases. 2015 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32738838017 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.87 |
| format | Artículo científico |
| id | redalyc_32738838017 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system OLGA M.M.F. OLIVEIRA Multidisciplinaria (Ciencias Naturales y Exactas) low Nicotine vitamin E tryptophan myeloperoxidase Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system OLGA M.M.F. OLIVEIRA IGUATEMY L. BRUNETTI NAJEH M. KHALIL Multidisciplinaria (Ciencias Naturales y Exactas) low Nicotine vitamin E tryptophan myeloperoxidase In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases. 2015 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32738838017 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.87 |
| title | Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) low Nicotine vitamin E tryptophan myeloperoxidase |
| url | https://www.redalyc.org/articulo.oa?id=32738838017 |