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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2015
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32739721014 |
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Table of Contents:
- Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris LUCIANA M.R. ANTINARELLI NÍCOLAS C. PINTO ELITA SCIO LAINE S. COIMBRA Multidisciplinaria (Ciencias Naturales y Exactas) Brazil medicinal plants natural products Casearia sylvestris leishmanicidal activity Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda , Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC 50 values below of 20 μg/mL against at least one species of Leishmania . Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC 50 values of 5.4 μg/mL, 5.0 μg/mL, 8.5 μg/mL and 7.7 μg/ mL for L. amazonensis , L. braziliensis , L. chagasi and L. major , respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC 50 value of 5.2 μg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC 50 value of 1.3 μg/ mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds. 2015 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32739721014 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.87