Molecular biology of mycoplasmas: from the minimum cell concept to the artificial cell
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| Format: | Artículo científico |
| Sprache: | en |
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Academia Brasileira de Ciências
2016
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| _version_ | 1876461645719404544 |
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| author | CAIO M.M. CORDOVA |
| author_facet | CAIO M.M. CORDOVA |
| contents | Molecular biology of mycoplasmas: from the minimum cell concept to the artificial cell CAIO M.M. CORDOVA DANIELA L. HOELTGEBAUM LAÍS D.P.N. MACHADO LARISSA DOS SANTOS Multidisciplinaria (Ciencias Naturales y Exactas) Mycoplasma molecular biology synthetic biology microbial genetics gene transfer techniques Mycoplasmas are a large group of bacteria, sorted into different genera in the Mollicutes class, whose main characteristic in common, besides the small genome, is the absence of cell wall. They are considered cellular and molecular biology study models. We present an updated review of the molecular biology of these model microorganisms and the development of replicative vectors for the transformation of mycoplasmas. Synthetic biology studies inspired by these pioneering works became possible and won the attention of the mainstream media. For the fi rst time, an artifi cial genome was synthesized (a minimal genome produced from consensus sequences obtained from mycoplasmas). For the fi rst time, a functional artifi cial cell has been constructed by introducing a genome completely synthesized within a cell envelope of a mycoplasma obtained by transformation techniques. Therefore, this article offers an updated insight to the state of the art of these peculiar organisms’ molecular biology. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32746362015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.88 |
| format | Artículo científico |
| id | redalyc_32746362015 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Molecular biology of mycoplasmas: from the minimum cell concept to the artificial cell CAIO M.M. CORDOVA Multidisciplinaria (Ciencias Naturales y Exactas) Mycoplasma molecular biology synthetic biology microbial genetics gene transfer techniques Molecular biology of mycoplasmas: from the minimum cell concept to the artificial cell CAIO M.M. CORDOVA DANIELA L. HOELTGEBAUM LAÍS D.P.N. MACHADO LARISSA DOS SANTOS Multidisciplinaria (Ciencias Naturales y Exactas) Mycoplasma molecular biology synthetic biology microbial genetics gene transfer techniques Mycoplasmas are a large group of bacteria, sorted into different genera in the Mollicutes class, whose main characteristic in common, besides the small genome, is the absence of cell wall. They are considered cellular and molecular biology study models. We present an updated review of the molecular biology of these model microorganisms and the development of replicative vectors for the transformation of mycoplasmas. Synthetic biology studies inspired by these pioneering works became possible and won the attention of the mainstream media. For the fi rst time, an artifi cial genome was synthesized (a minimal genome produced from consensus sequences obtained from mycoplasmas). For the fi rst time, a functional artifi cial cell has been constructed by introducing a genome completely synthesized within a cell envelope of a mycoplasma obtained by transformation techniques. Therefore, this article offers an updated insight to the state of the art of these peculiar organisms’ molecular biology. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32746362015 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.88 |
| title | Molecular biology of mycoplasmas: from the minimum cell concept to the artificial cell |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Mycoplasma molecular biology synthetic biology microbial genetics gene transfer techniques |
| url | https://www.redalyc.org/articulo.oa?id=32746362015 |