Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2016
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| author | Lorena M.D. Cirino |
| author_facet | Lorena M.D. Cirino |
| contents | Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes Lorena M.D. Cirino Daviane M.C. Vergne Patrícia F. Santana Enrik De Almeida Luiz P. Da Costa Ricardo L.C. De Albuquerque-Júnior Isabel B. Lima-Verde Francine F. Padilha Juliana C. Cardoso Multidisciplinaria (Ciencias Naturales y Exactas) Capsaicin liposomes urinary incontinence intravesical administration The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around-30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32746972032 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.88 |
| format | Artículo científico |
| id | redalyc_32746972032 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes Lorena M.D. Cirino Multidisciplinaria (Ciencias Naturales y Exactas) Capsaicin liposomes urinary incontinence intravesical administration Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes Lorena M.D. Cirino Daviane M.C. Vergne Patrícia F. Santana Enrik De Almeida Luiz P. Da Costa Ricardo L.C. De Albuquerque-Júnior Isabel B. Lima-Verde Francine F. Padilha Juliana C. Cardoso Multidisciplinaria (Ciencias Naturales y Exactas) Capsaicin liposomes urinary incontinence intravesical administration The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around-30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32746972032 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.88 |
| title | Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Capsaicin liposomes urinary incontinence intravesical administration |
| url | https://www.redalyc.org/articulo.oa?id=32746972032 |