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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2016
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32748476021 |
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Table of Contents:
- Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex Francine R. Ianiski Virginia C. Rech Vivian S.K. Nishihira Catiane B. Alves Matheus D. Baldissera Ethel A. Wilhelm Cristiane Luchese Multidisciplinaria (Ciencias Naturales y Exactas) meloxicam nanoparticles Alzheimer’s disease energetic metabolism phosphoryltransfer network Considering that Alzheimer’s disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer’s disease model. Male adult Swiss mice received amyloid-β or saline. One day after, mice were treated with blank nanocapsules (17 ml/kg) or meloxicam-loaded nanocapsules (5 mg/kg) or free meloxicam (5 mg/kg). Treatments were performed on alternating days, until the end of the experimental protocol. In the fourteenth day, kinases activities were performed. Amyloid-β did not change the kinases activity in the hippocampus and cerebral cortex of mice. However, free meloxicam decrease the creatine kinase activity in mitochondrial-rich fraction in the group induced by amyloid-β, but for the cytosolic fraction, it has raised in the activity of pyruvate kinase activity in cerebral cortex. Further, meloxicam-loaded nanocapsules administration reduced adenylate kinase activity in the hippocampus of mice injected by amyloid-β. In conclusion we observed absence in short-term effects in kinases activities of energy metabolism in mice hippocampus and cerebral cortex using amyloid-β peptide model. These findings established the foundation to further study the kinases in phosphoryltransfer network changes observed in the brains of patients post-mortem with Alzheimer’s disease. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32748476021 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.88