Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Academia Brasileira de Ciências
2016
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=32748476031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Atheroprotective action of a modified organoselenium compound: in vitro evidence Jade de Oliveira Marcos R. Straliotto Gianni Mancini Claudia P. Figueiredo Antônio L. Braga João B.R. Teixeira Andreza F. Bem Multidisciplinaria (Ciencias Naturales y Exactas) GPx foam cell Compound HBD like activity LDL oxidation Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organoselenium compounds have demonstrated promising atheroprotective properties in experimental models. Herein, we tested the in vitro atheroprotective capability of a modified organoselenium compound, Compound HBD, in protecting isolated LDL from oxidation as well as foam cells formation. Moreover, the glutathione peroxidase (GPx)-like activity of Compound HBD was analyzed in order to explore the mechanisms related to the above-mentioned protective effects. The Compound HBD in a concentration-dependent manner reduced the Cu2+-induced formation of conjugated dienes. The protein portion from LDL were also protected from Cu2+-induced oxidation. Furthermore, the Compound HBD efficiently decreased the foam cell formation in J774 macrophage cells exposed to oxidized LDL. We found that the atheroprotective effects of this compound can be, at least in part, related to its GPxlike activity. Our findings demonstrated an impressive effect of Compound HBD against LDL-induced toxicity, a further in vivo study to investigate in more detail the antioxidant and antiatherogenic effects of this compound could be considered. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32748476031 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.88