Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae)
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2016
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| _version_ | 1876485498511294464 |
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| author | KELVIN S.E. LÓPEZ |
| author_facet | KELVIN S.E. LÓPEZ |
| contents | Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae) KELVIN S.E. LÓPEZ ANDRÉ M. MARQUES DAVYSON DE L. MOREIRA LEOSVALDO S. VELOZO ROBERTO T. SUDO GISELE ZAPATA-SUDO ELSIE F. GUIMARÃES MARIA AUXILIADORA C. KAPLAN Multidisciplinaria (Ciencias Naturales y Exactas) Piper amides Ottonia Piperaceae sensory blockage Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as “anestesia” and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three amides (pipercallosidine, piperine and valeramide) and in an enriched mixture of seven amides (valeramide, 4,5-dihydropiperlonguminine, N -isobutil-6-piperonil-2-hexenamide, piperovatine, dihydropipercallosidine, pipercallosidine and pipercallpsine). Our findings demonstrated the anesthetic potential for the methanolic extract from roots, its n -hexane partition and amides from O. anisum and it is in agreement with ethnobotanical survey. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32748882016 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.88 |
| format | Artículo científico |
| id | redalyc_32748882016 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae) KELVIN S.E. LÓPEZ Multidisciplinaria (Ciencias Naturales y Exactas) Piper amides Ottonia Piperaceae sensory blockage Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae) KELVIN S.E. LÓPEZ ANDRÉ M. MARQUES DAVYSON DE L. MOREIRA LEOSVALDO S. VELOZO ROBERTO T. SUDO GISELE ZAPATA-SUDO ELSIE F. GUIMARÃES MARIA AUXILIADORA C. KAPLAN Multidisciplinaria (Ciencias Naturales y Exactas) Piper amides Ottonia Piperaceae sensory blockage Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as “anestesia” and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three amides (pipercallosidine, piperine and valeramide) and in an enriched mixture of seven amides (valeramide, 4,5-dihydropiperlonguminine, N -isobutil-6-piperonil-2-hexenamide, piperovatine, dihydropipercallosidine, pipercallosidine and pipercallpsine). Our findings demonstrated the anesthetic potential for the methanolic extract from roots, its n -hexane partition and amides from O. anisum and it is in agreement with ethnobotanical survey. 2016 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32748882016 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.88 |
| title | Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae) |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Piper amides Ottonia Piperaceae sensory blockage |
| url | https://www.redalyc.org/articulo.oa?id=32748882016 |