Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2017
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| _version_ | 1876431308249366528 |
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| author | ROCIO GÓMEZ-CANSINO |
| author_facet | ROCIO GÓMEZ-CANSINO |
| contents | Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs ROCIO GÓMEZ-CANSINO SILVIA LAURA GUZMÁN-GUTIÉRREZ MARÍA GUADALUPE CAMPOS-LARA CLARA INES ESPITIA-PINZÓN RICARDO REYES-CHILPA Multidisciplinaria (Ciencias Naturales y Exactas) Tuberculosis medicinal plants natural products Mycobacterium tuberculosis In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 μg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 μg/mL). Other potent extracts (inhibition > 95%, 50 μg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identi¿ed, the most potent are: Licarin A (isolated from A. taliscana), and 9-amino-9-methoxy-3,4-dihydro-2H-benzo[h]-chromen-2-one (transformation product of 9-methoxytariacuripyrone isolated from Aristolochia brevipes), both with MIC= 3.125 μg/mL, that is 8-fold less potent than the reference drug Rifampicin (MIC= 0.5 μg/mL). Any of the compounds or extracts here reviewed has been studied in clinical trials or with animal models; however, these should be accomplished since several are active against strains resistant to common drugs. 2017 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32750457004 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.89 |
| format | Artículo científico |
| id | redalyc_32750457004 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs ROCIO GÓMEZ-CANSINO Multidisciplinaria (Ciencias Naturales y Exactas) Tuberculosis medicinal plants natural products Mycobacterium tuberculosis Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs ROCIO GÓMEZ-CANSINO SILVIA LAURA GUZMÁN-GUTIÉRREZ MARÍA GUADALUPE CAMPOS-LARA CLARA INES ESPITIA-PINZÓN RICARDO REYES-CHILPA Multidisciplinaria (Ciencias Naturales y Exactas) Tuberculosis medicinal plants natural products Mycobacterium tuberculosis In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 μg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 μg/mL). Other potent extracts (inhibition > 95%, 50 μg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identi¿ed, the most potent are: Licarin A (isolated from A. taliscana), and 9-amino-9-methoxy-3,4-dihydro-2H-benzo[h]-chromen-2-one (transformation product of 9-methoxytariacuripyrone isolated from Aristolochia brevipes), both with MIC= 3.125 μg/mL, that is 8-fold less potent than the reference drug Rifampicin (MIC= 0.5 μg/mL). Any of the compounds or extracts here reviewed has been studied in clinical trials or with animal models; however, these should be accomplished since several are active against strains resistant to common drugs. 2017 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32750457004 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.89 |
| title | Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Tuberculosis medicinal plants natural products Mycobacterium tuberculosis |
| url | https://www.redalyc.org/articulo.oa?id=32750457004 |