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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32751053014 |
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Table of Contents:
- Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalie Ibrahim Chahoud FRANCISCO J.R. PAUMGARTTEM Multidisciplinaria (Ciencias Naturales y Exactas) mouse strains teratogenicity Alkylating agents phase specificity embryo development The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter- strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI: GD 9, 9 1/2 or 10; DBA/2J: GD 10 or 10 1/2 ). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar –with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted. 2017 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32751053014 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.89