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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32753602001 |
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Table of Contents:
- A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus GABRIEL F. DOS SANTOS JACQUELINE A. TAKAHASHI Multidisciplinaria (Ciencias Naturales y Exactas) 19 oic acid trachyloban Mucor plumbeus biotransformation The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid ( 1 ), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid ( 5 ) and trachyloban-19- O -β- D -glucopyranosyl ester ( 6 ). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 μg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines. 2017 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32753602001 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.89