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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32753602040 |
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Table of Contents:
- In vitro antifungal activity of Myracrodruon urundeuva Allemão against human vaginal Candida species FERNANDO A. DE OLIVEIRA VANESSA C. RORATO ADRIANA A. ALMEIDA-APOLONIO ALLAN B. RODRIGUES ALINE L. DE BARROS ANDRÉIA SANGALLI ARIELLE C. ARENA JONAS S. MOTA ALEXÉIA B. GRISOLIA KELLY M.P. DE OLIVEIRA Multidisciplinaria (Ciencias Naturales y Exactas) candidiasis Anacardiaceae traditional medicine Myracrodruon urundeuva Myracrodruon urundeuva is a plant native to Brazil, which is used by the indigenous population for the treatment of candidiasis. The aims of this study were to evaluate the antifungal activity of extract against human vaginal Candida species and evaluate the possible toxicological activities of M. urundeuva . Initially, ethanol extracts, ethyl acetate fractions, and hydroalcoholic fractions of the bark and leaf of M. urundeuva were used to determine the minimum inhibitory concentration. The extracts that showed antifungal activity were characterized by liquid chromatography and subjected to toxicity assessment. Toxic, cytotoxic, genotoxic, and mutagenic testing were performed using Allium cepa and Ames assays with the ethanol extracts of the bark and leaves. Hemolytic activity was evaluated in erythrocytes and acute toxicity in rats. The ethanol bark extracts showed best activity against Candida albicans, C. krusei, and C. tropicalis ATCC (4-512 μ g/mL). Chemical characterization indicated the presence of flavonoids and tannins in the extracts. Hemolytic activity, genotoxicity, and mutagenicity were not observed. The results of the Ames and A. cepa tests were also in agreement, ethanol bark extracts and ethanol leaf extracts of M. urundeuva showed absence of mutagenic activity. Similar results were observed in the A. cepa assay and acute toxicity test in rats . M. urundeuva bark extracts showed potential for the treatment of vaginal infections caused Candida species, as a topical. 2017 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32753602040 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.89