Interactions between cationic liposomes and drugs or biomolecules
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| Format: | Artículo científico |
| Sprache: | en |
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Academia Brasileira de Ciências
2000
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| _version_ | 1876457316232986624 |
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| author | Ana Maria Ribeiro Carmona |
| author_facet | Ana Maria Ribeiro Carmona |
| contents | Interactions between cationic liposomes and drugs or biomolecules Ana Maria Ribeiro Carmona Multidisciplinaria (Ciencias Naturales y Exactas) drugs surfaces liposomes interactions phospholipids Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide(DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in thecationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteriaand fungi at concentrations that barely affect mammalian cells in culture. Silica particles or polystyrenemicrospheres can be functionalized by coverage with DODAB bilayers or phospholipid monolayers. Negativelycharged antigenic proteins can be carried by the cationic liposomes which generate a remarkableimmunoadjuvant action. Nucleotides or DNA can be physically adsorbed to the cationic liposomes to betransferred to mammalian cells for gene therapy. An overview of the interactions between DODAB vesiclesand some biomolecules or drugs clearly points out their versatility for useful applications in a near future. 2000 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32772105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.72 |
| format | Artículo científico |
| id | redalyc_32772105 |
| institution | Redalyc |
| language | en |
| publishDate | 2000 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Interactions between cationic liposomes and drugs or biomolecules Ana Maria Ribeiro Carmona Multidisciplinaria (Ciencias Naturales y Exactas) drugs surfaces liposomes interactions phospholipids Interactions between cationic liposomes and drugs or biomolecules Ana Maria Ribeiro Carmona Multidisciplinaria (Ciencias Naturales y Exactas) drugs surfaces liposomes interactions phospholipids Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide(DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in thecationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteriaand fungi at concentrations that barely affect mammalian cells in culture. Silica particles or polystyrenemicrospheres can be functionalized by coverage with DODAB bilayers or phospholipid monolayers. Negativelycharged antigenic proteins can be carried by the cationic liposomes which generate a remarkableimmunoadjuvant action. Nucleotides or DNA can be physically adsorbed to the cationic liposomes to betransferred to mammalian cells for gene therapy. An overview of the interactions between DODAB vesiclesand some biomolecules or drugs clearly points out their versatility for useful applications in a near future. 2000 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32772105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.72 |
| title | Interactions between cationic liposomes and drugs or biomolecules |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) drugs surfaces liposomes interactions phospholipids |
| url | https://www.redalyc.org/articulo.oa?id=32772105 |