Genetic modification of Mammalian Genome at Chromosome level
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2000
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| _version_ | 1876463168114393088 |
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| author | Oleg L. Serov |
| author_facet | Oleg L. Serov |
| contents | Genetic modification of Mammalian Genome at Chromosome level Oleg L. Serov Natalia M. Matveeva Irina A. Serova Pavel M. Borodin Multidisciplinaria (Ciencias Naturales y Exactas) Cre MAC loxP ES cells chromosome biotechnology The reviewis concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo atchromosomal level. Recently three newapproaches for the chromosome biotechnology have been developed:Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes ortheir segments or particular genes within the genome, and therefore to modify the set, position and copynumber of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide apossibility to introduce into genome relatively large segments of alien chromosome material, either artificiallyconstructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transferwhole chromosomes or their fragments between different genomes within and between species. Advantagesand limitations of these approaches are discussed. 2000 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32772312 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.72 |
| format | Artículo científico |
| id | redalyc_32772312 |
| institution | Redalyc |
| language | en |
| publishDate | 2000 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Genetic modification of Mammalian Genome at Chromosome level Oleg L. Serov Multidisciplinaria (Ciencias Naturales y Exactas) Cre MAC loxP ES cells chromosome biotechnology Genetic modification of Mammalian Genome at Chromosome level Oleg L. Serov Natalia M. Matveeva Irina A. Serova Pavel M. Borodin Multidisciplinaria (Ciencias Naturales y Exactas) Cre MAC loxP ES cells chromosome biotechnology The reviewis concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo atchromosomal level. Recently three newapproaches for the chromosome biotechnology have been developed:Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes ortheir segments or particular genes within the genome, and therefore to modify the set, position and copynumber of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide apossibility to introduce into genome relatively large segments of alien chromosome material, either artificiallyconstructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transferwhole chromosomes or their fragments between different genomes within and between species. Advantagesand limitations of these approaches are discussed. 2000 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32772312 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.72 |
| title | Genetic modification of Mammalian Genome at Chromosome level |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Cre MAC loxP ES cells chromosome biotechnology |
| url | https://www.redalyc.org/articulo.oa?id=32772312 |