The lizard cerebral cortex as a model to study neuronal regeneration
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Academia Brasileira de Ciências
2002
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| _version_ | 1876466755538255872 |
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| author | Carlos López García |
| author_facet | Carlos López García |
| contents | The lizard cerebral cortex as a model to study neuronal regeneration Carlos López García Asunción Molowny Juan Nacher Xavier Ponsoda Francisco Sancho Bielsa Gregori Alonso Llosa Multidisciplinaria (Ciencias Naturales y Exactas) zinc hippocampus regeneration medial cortex neural stem cells The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayedpostnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons,which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axonsdirected to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zincenrichedaxonal projection. This happens along the lizard life span, even in adult lizards, thus allowing oneof their most important characteristics: neuronal regeneration.Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% ofits neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and,secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regenerationof an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only caseto our knowledge of the regeneration of an amniote central nervous centre by new neuron production andneo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and thecomplex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774106 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.74 |
| format | Artículo científico |
| id | redalyc_32774106 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The lizard cerebral cortex as a model to study neuronal regeneration Carlos López García Multidisciplinaria (Ciencias Naturales y Exactas) zinc hippocampus regeneration medial cortex neural stem cells The lizard cerebral cortex as a model to study neuronal regeneration Carlos López García Asunción Molowny Juan Nacher Xavier Ponsoda Francisco Sancho Bielsa Gregori Alonso Llosa Multidisciplinaria (Ciencias Naturales y Exactas) zinc hippocampus regeneration medial cortex neural stem cells The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayedpostnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons,which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axonsdirected to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zincenrichedaxonal projection. This happens along the lizard life span, even in adult lizards, thus allowing oneof their most important characteristics: neuronal regeneration.Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% ofits neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and,secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regenerationof an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only caseto our knowledge of the regeneration of an amniote central nervous centre by new neuron production andneo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and thecomplex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774106 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.74 |
| title | The lizard cerebral cortex as a model to study neuronal regeneration |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) zinc hippocampus regeneration medial cortex neural stem cells |
| url | https://www.redalyc.org/articulo.oa?id=32774106 |