Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates
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Academia Brasileira de Ciências
2002
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| _version_ | 1876477014675816448 |
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| author | Mauro S. G. Pavão |
| author_facet | Mauro S. G. Pavão |
| contents | Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates Mauro S. G. Pavão Multidisciplinaria (Ciencias Naturales y Exactas) heparin ascidian anticoagulant antithrombotic dermatan sulfate Dermatan sulfates and heparin, similar to the mammalian glycosaminoglycans, but with differences in thedegree and position of sulfation were previously isolated from the body of the ascidian Styela plicata andAscidia nigra. These differences produce profound effects on their anticoagulant properties. S. plicatadermatan sulfate composed by 2-O-sulfated α-L-iduronic acid and 4-O-sulfated N-acetyl-β-D-galactosamineresidues is a potent anticoagulant due to a high heparin cofactor II activity. Surprisingly, it has a lowerpotency to prevent thrombus formation on an experimental model and a lower bleeding effect in rats thanthe mammalian dermatan sulfate. In contrast, A. nigra dermatan sulfate, also enriched in 2-O-sulfated α-Liduronicacid, but in this case sulfated at O-6 of the N-acetyl-β-D-galactosamine units, has no in vitro or invivo anticoagulant activity, does not prevent thrombus formation but shows a bleeding effect similar to themammalian glycosaminoglycan. Ascidian heparin, composed by 2-O-sulfated α-L-iduronic acid, N- and 6-O-sulfated glucosamine (75%) and α-L-iduronic acid, N- and 6-O-sulfated glucosamine (25%) disaccharideunits has an anticoagulant activity 10 times lower than the mammalian heparin, is about 20 times less potentin the inhibition of thrombin by antithrombin, but has the same heparin cofactor II activity as mammalianheparin. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774107 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.74 |
| format | Artículo científico |
| id | redalyc_32774107 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates Mauro S. G. Pavão Multidisciplinaria (Ciencias Naturales y Exactas) heparin ascidian anticoagulant antithrombotic dermatan sulfate Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates Mauro S. G. Pavão Multidisciplinaria (Ciencias Naturales y Exactas) heparin ascidian anticoagulant antithrombotic dermatan sulfate Dermatan sulfates and heparin, similar to the mammalian glycosaminoglycans, but with differences in thedegree and position of sulfation were previously isolated from the body of the ascidian Styela plicata andAscidia nigra. These differences produce profound effects on their anticoagulant properties. S. plicatadermatan sulfate composed by 2-O-sulfated α-L-iduronic acid and 4-O-sulfated N-acetyl-β-D-galactosamineresidues is a potent anticoagulant due to a high heparin cofactor II activity. Surprisingly, it has a lowerpotency to prevent thrombus formation on an experimental model and a lower bleeding effect in rats thanthe mammalian dermatan sulfate. In contrast, A. nigra dermatan sulfate, also enriched in 2-O-sulfated α-Liduronicacid, but in this case sulfated at O-6 of the N-acetyl-β-D-galactosamine units, has no in vitro or invivo anticoagulant activity, does not prevent thrombus formation but shows a bleeding effect similar to themammalian glycosaminoglycan. Ascidian heparin, composed by 2-O-sulfated α-L-iduronic acid, N- and 6-O-sulfated glucosamine (75%) and α-L-iduronic acid, N- and 6-O-sulfated glucosamine (25%) disaccharideunits has an anticoagulant activity 10 times lower than the mammalian heparin, is about 20 times less potentin the inhibition of thrombin by antithrombin, but has the same heparin cofactor II activity as mammalianheparin. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774107 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.74 |
| title | Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) heparin ascidian anticoagulant antithrombotic dermatan sulfate |
| url | https://www.redalyc.org/articulo.oa?id=32774107 |