New enamine derivatives of lapachol and biological activity
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2002
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| _version_ | 1876436708966268928 |
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| author | Mailcar F. Oliveira |
| author_facet | Mailcar F. Oliveira |
| contents | New enamine derivatives of lapachol and biological activity Mailcar F. Oliveira Telma L. G. Lemos Marcos C. de Mattos Taciana A. Segundo Gilvandete M. P. Santiago Raimundo Braz Filho Multidisciplinaria (Ciencias Naturales y Exactas) lapachol enamine derivatives biological activities A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the productswere established mainly by NMR analysis, including 2D experiments. Biological activities of these productswere evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774204 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.74 |
| format | Artículo científico |
| id | redalyc_32774204 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | New enamine derivatives of lapachol and biological activity Mailcar F. Oliveira Multidisciplinaria (Ciencias Naturales y Exactas) lapachol enamine derivatives biological activities New enamine derivatives of lapachol and biological activity Mailcar F. Oliveira Telma L. G. Lemos Marcos C. de Mattos Taciana A. Segundo Gilvandete M. P. Santiago Raimundo Braz Filho Multidisciplinaria (Ciencias Naturales y Exactas) lapachol enamine derivatives biological activities A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the productswere established mainly by NMR analysis, including 2D experiments. Biological activities of these productswere evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774204 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.74 |
| title | New enamine derivatives of lapachol and biological activity |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) lapachol enamine derivatives biological activities |
| url | https://www.redalyc.org/articulo.oa?id=32774204 |