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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32774307 |
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| _version_ | 1866815443243630592 |
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| author | Roberto Paes de Carvalho |
| author_facet | Roberto Paes de Carvalho |
| contents | Adenosine as a signaling molecule in the retina: biochemical and developmental aspects Roberto Paes de Carvalho Multidisciplinaria (Ciencias Naturales y Exactas) nucleoside development cell culture uptake and release receptors and transporters The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the centralnervous system, including the retina. In the present paper we review compelling evidence showing thatadenosine is a signaling molecule in the developing retina. In the chick retina, adenosine transportersare present since early stages of development before the appearance of adenosine A1 receptors modulatingdopamine-dependent adenylate cyclase activity orA2receptors that directly activate the enzyme. Experimentsusing retinal cell cultures revealed that adenosine is taken up by specific cell populations that when stimulatedby depolarization or neurotransmitters such as dopamine or glutamate, release the nucleoside through calciumdependenttransporter-mediated mechanisms. The presence of adenosine in the extracellular medium andthe long-term activation of adenosine receptors is able to regulate the survival of retinal neurons and blocksglutamate excitoxicity. Thus, adenosine besides working as a neurotransmitter or neuromodulator in themature retina, is considered as an important signaling molecule during retinal development having importantfunctions such as regulation of neuronal survival and differentiation. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774307 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.74 |
| format | Artículo científico |
| id | redalyc_32774307 |
| language | en |
| publishDate | 2002 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Adenosine as a signaling molecule in the retina: biochemical and developmental aspects Roberto Paes de Carvalho Multidisciplinaria (Ciencias Naturales y Exactas) nucleoside development cell culture uptake and release receptors and transporters Adenosine as a signaling molecule in the retina: biochemical and developmental aspects Roberto Paes de Carvalho Multidisciplinaria (Ciencias Naturales y Exactas) nucleoside development cell culture uptake and release receptors and transporters The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the centralnervous system, including the retina. In the present paper we review compelling evidence showing thatadenosine is a signaling molecule in the developing retina. In the chick retina, adenosine transportersare present since early stages of development before the appearance of adenosine A1 receptors modulatingdopamine-dependent adenylate cyclase activity orA2receptors that directly activate the enzyme. Experimentsusing retinal cell cultures revealed that adenosine is taken up by specific cell populations that when stimulatedby depolarization or neurotransmitters such as dopamine or glutamate, release the nucleoside through calciumdependenttransporter-mediated mechanisms. The presence of adenosine in the extracellular medium andthe long-term activation of adenosine receptors is able to regulate the survival of retinal neurons and blocksglutamate excitoxicity. Thus, adenosine besides working as a neurotransmitter or neuromodulator in themature retina, is considered as an important signaling molecule during retinal development having importantfunctions such as regulation of neuronal survival and differentiation. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774307 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.74 |
| title | Adenosine as a signaling molecule in the retina: biochemical and developmental aspects |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) nucleoside development cell culture uptake and release receptors and transporters |
| url | https://www.redalyc.org/articulo.oa?id=32774307 |