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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32774409 |
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Table of Contents:
- Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth Marcienne Tardy Multidisciplinaria (Ciencias Naturales y Exactas) neuro laminin astrogliosis glia interactions neurite outgrowth The mechanisms involved in the failure of an adult brain to regenerate post-lesion remain poorly understood.The reactive gliosis which occurs after an injury to the CNS and leads to the glial scar has been considered asone of the major impediments to neurite outgrowth and axonal regeneration. A glial scar consists mainly ofreactive, hypertrophic astrocytes. These reactive cells acquire new properties, leading to A non-permissivesupport for neurons. Astrogial reactivity is mainly characteriized by a high overexpression of the major componentof the gliofilaments, the glial fibrillary acidic protein (GFAP). This GFAP overexpression is relatedto the astroglial morphological response to injury. We hypothesized that modulation of GFAP synthesis,reversing the hypertrophic phenotype, might also reverse the blockage of neuritic outgrowth observed aftera lesion. In this article, we review findings of our group, confirming our hypothesis in a model of lesionedneuron-astrocyte cocultures. We demonstrate that permissivity for neuritic outgrowth is related to phenotypicchanges induced in reactive astrocytes transfected by antisense GFAP-mRNA.We also found that thispermissivity was related to a neuron-regulated extracellular laminin bioavailability. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774409 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.74