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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32774410 |
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Table of Contents:
- Modulators of axonal growth and guidance at the brain midline with special reference to glial heparan sulfate proteoglycans José Garcia Abreu Vivaldo Moura Neto Luiz Claudio Silva Gilberto Weissmüller Leny A. Cavalcante Multidisciplinaria (Ciencias Naturales y Exactas) midline midbrain astrocytes axon growth heparan sulfate Bilaterally symmetric organisms need to exchange information between the left and right sides of theirbodies to integrate sensory input and to coordinate motor control. Thus, an important choice point fordeveloping axons is the Central Nervous System (CNS) midline. Crossing of this choice point is influencedby highly conserved, soluble or membrane-bound molecules such as the L1 subfamily, laminin, netrins, slits,semaphorins, Eph-receptors and ephrins, etc. Furthermore, there is much circumstantial evidence for a roleof proteoglycans (PGs) or their glycosaminoglycan (GAG) moieties on axonal growth and guidance, most ofwhichwas derived from simplified models. Amodel of intermediate complexity is that of cocultures of youngneurons and astroglial carpets (confluent cultures) obtained from medial and lateral sectors of the embryonicrodent midbrain soon after formation of its commissures. Neurite production in these cocultures reveals that,irrespective of the previous location of neurons in the midbrain, medial astrocytes exerted an inhibitory or nonpermissiveeffect on neuritic growth that was correlated to a higher content of both heparan and chondroitinsulfates (HS and CS). Treatment with GAG lyases shows minor effects of CS and discloses a major inhibitoryor non-permissive role for HS. The results are discussed in terms of available knowledge on the binding ofHSPGs to interative proteins and underscore the importance of understanding glial polysaccharide arrays inaddition to its protein complement for a better understanding of neuron-glial interactions. 2002 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32774410 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.74