Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
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| Format: | Artículo científico |
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Academia Brasileira de Ciências
2003
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| author | Mauricio M. Rodrigues |
| author_facet | Mauricio M. Rodrigues |
| contents | Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines Mauricio M. Rodrigues Silvia B. Boscardin José R. Vasconcelos Gerson Salay Irene S. Soares Multidisciplinaria (Ciencias Naturales y Exactas) CD8 vaccine immunity parasites Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmaniasp are responsible for the infection of hundreds of millions of individuals every year. These parasitescan deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protectiveCD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largelyunknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated byCD8 T cells include both interferon-γ -dependent and -independent pathways. The fact that CD8 T cells arepotent inhibitors of parasitic development prompted many investigators to explore whether induction of theseT cells can be a feasible strategy for the development of effective subunit vaccines against these parasiticdiseases. Studies performed on experimental models supported the hypothesis that CD8 T cells inducedby recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimensof immunization consisting of two different vectors (heterologous prime-boost) are much more efficient interms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The resultsobtained using experimental models have led to clinical vaccination trials that are currently underway. 2003 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32775405 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.75 |
| format | Artículo científico |
| id | redalyc_32775405 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines Mauricio M. Rodrigues Multidisciplinaria (Ciencias Naturales y Exactas) CD8 vaccine immunity parasites Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines Mauricio M. Rodrigues Silvia B. Boscardin José R. Vasconcelos Gerson Salay Irene S. Soares Multidisciplinaria (Ciencias Naturales y Exactas) CD8 vaccine immunity parasites Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmaniasp are responsible for the infection of hundreds of millions of individuals every year. These parasitescan deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protectiveCD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largelyunknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated byCD8 T cells include both interferon-γ -dependent and -independent pathways. The fact that CD8 T cells arepotent inhibitors of parasitic development prompted many investigators to explore whether induction of theseT cells can be a feasible strategy for the development of effective subunit vaccines against these parasiticdiseases. Studies performed on experimental models supported the hypothesis that CD8 T cells inducedby recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimensof immunization consisting of two different vectors (heterologous prime-boost) are much more efficient interms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The resultsobtained using experimental models have led to clinical vaccination trials that are currently underway. 2003 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32775405 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.75 |
| title | Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) CD8 vaccine immunity parasites |
| url | https://www.redalyc.org/articulo.oa?id=32775405 |