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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2004
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32776105 |
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| _version_ | 1866812396839895040 |
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| author | Cleverson Busso |
| author_facet | Cleverson Busso |
| contents | Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans Cleverson Busso Marialba A. A. Castro-Prado Multidisciplinaria (Ciencias Naturales y Exactas) cremophor EL antineoplasm agents Aspergillus nidulans mitotic recombination Homozygotization Index Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel´s clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were determined for the evaluation of the recombinagenic effect of cremophor EL. It has been shown that cremophor EL induces increase in mitotic crossing-over events at nontoxic concentrations (0.05 and 0.075% v/v). 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.76 |
| format | Artículo científico |
| id | redalyc_32776105 |
| language | en |
| publishDate | 2004 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans Cleverson Busso Multidisciplinaria (Ciencias Naturales y Exactas) cremophor EL antineoplasm agents Aspergillus nidulans mitotic recombination Homozygotization Index Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans Cleverson Busso Marialba A. A. Castro-Prado Multidisciplinaria (Ciencias Naturales y Exactas) cremophor EL antineoplasm agents Aspergillus nidulans mitotic recombination Homozygotization Index Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel´s clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were determined for the evaluation of the recombinagenic effect of cremophor EL. It has been shown that cremophor EL induces increase in mitotic crossing-over events at nontoxic concentrations (0.05 and 0.075% v/v). 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.76 |
| title | Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) cremophor EL antineoplasm agents Aspergillus nidulans mitotic recombination Homozygotization Index |
| url | https://www.redalyc.org/articulo.oa?id=32776105 |