Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2004
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| _version_ | 1876454767782264832 |
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| author | Maria Elisabete C. Moreira |
| author_facet | Maria Elisabete C. Moreira |
| contents | Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems Maria Elisabete C. Moreira Marcello A. Barcinski Multidisciplinaria (Ciencias Naturales y Exactas) apoptosis phagocyte cell death apoptotic mimicry intracellular signaling Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776109 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.76 |
| format | Artículo científico |
| id | redalyc_32776109 |
| institution | Redalyc |
| language | en |
| publishDate | 2004 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems Maria Elisabete C. Moreira Multidisciplinaria (Ciencias Naturales y Exactas) apoptosis phagocyte cell death apoptotic mimicry intracellular signaling Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems Maria Elisabete C. Moreira Marcello A. Barcinski Multidisciplinaria (Ciencias Naturales y Exactas) apoptosis phagocyte cell death apoptotic mimicry intracellular signaling Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776109 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.76 |
| title | Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) apoptosis phagocyte cell death apoptotic mimicry intracellular signaling |
| url | https://www.redalyc.org/articulo.oa?id=32776109 |