Genes and chromosomes: control of development
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2004
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| _version_ | 1876483187817840640 |
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| author | Irina Serova |
| author_facet | Irina Serova |
| contents | Genes and chromosomes: control of development Irina Serova Oleg Serov Multidisciplinaria (Ciencias Naturales y Exactas) genetic networks developmental genes epigenetic regulation chromosome territories variegated position effect The past decade has witnessed immense progress in research into the molecular basis behind the developmental regulation of genes. Sets of genes functioning under hierarchical control have been identified, evolutionary conserved systems of genes effecting the cell-to-cell transmission of transmembrane signals and assigned a central role in morphogenesis have been intensively studied; the concept of genomic regulatory networks coordinating expression of many genes has been introduced, to mention some of the major breakthroughs. It should be noted that the temporal and tissue-specific parameters of gene expression are correctly regulated in development only in the context of the chromosome and that they are to a great extent dependent on the position of the gene on the chromosome or the interphase nucleus. Moreover epigenetic inheritance of the gene states through successive cell generations has been conducted exclusively at the chromosome level by virtue of cell or chromosome memory. The ontogenetic memory is an inherent property of the chromosome and cis-regulation has a crucial role in its maintenance. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776307 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.76 |
| format | Artículo científico |
| id | redalyc_32776307 |
| institution | Redalyc |
| language | en |
| publishDate | 2004 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Genes and chromosomes: control of development Irina Serova Multidisciplinaria (Ciencias Naturales y Exactas) genetic networks developmental genes epigenetic regulation chromosome territories variegated position effect Genes and chromosomes: control of development Irina Serova Oleg Serov Multidisciplinaria (Ciencias Naturales y Exactas) genetic networks developmental genes epigenetic regulation chromosome territories variegated position effect The past decade has witnessed immense progress in research into the molecular basis behind the developmental regulation of genes. Sets of genes functioning under hierarchical control have been identified, evolutionary conserved systems of genes effecting the cell-to-cell transmission of transmembrane signals and assigned a central role in morphogenesis have been intensively studied; the concept of genomic regulatory networks coordinating expression of many genes has been introduced, to mention some of the major breakthroughs. It should be noted that the temporal and tissue-specific parameters of gene expression are correctly regulated in development only in the context of the chromosome and that they are to a great extent dependent on the position of the gene on the chromosome or the interphase nucleus. Moreover epigenetic inheritance of the gene states through successive cell generations has been conducted exclusively at the chromosome level by virtue of cell or chromosome memory. The ontogenetic memory is an inherent property of the chromosome and cis-regulation has a crucial role in its maintenance. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776307 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.76 |
| title | Genes and chromosomes: control of development |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) genetic networks developmental genes epigenetic regulation chromosome territories variegated position effect |
| url | https://www.redalyc.org/articulo.oa?id=32776307 |