Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2004
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| _version_ | 1876458693134909440 |
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| author | Elizabeth S. Machado |
| author_facet | Elizabeth S. Machado |
| contents | Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil Elizabeth S. Machado John S. Lambert Adriana O. Afonso Silvia M. Cunha Ricardo H. Oliveira Amilcar Tanuri Anne M. Sill Marcelo A. Soares Multidisciplinaria (Ciencias Naturales y Exactas) HIV subtype clinical pediatric genotyping Although mother-to-child HIV transmission prevention has slowed down pediatric HIV infection in developedcountries, large numbers of infants still become infected in developing nations. Data on pediatric HIVinfection is however largely scarce. In this study, we have overviewed clinical, laboratory and genotypic datafrom a large cohort of HIV-infected infants regularly followed at two pediatric HIV outpatient clinics in Riode Janeiro, Brazil. Children on antiretroviral therapy, as well as drug-naïve, newly diagnosed infants wereanalyzed. Prevalence of drug resistance mutations, as well as immunological and virological responses totherapy were evaluated. Additionally, HIV-1 subtype frequencies and their distribution over the course of theepidemic were studied. We have found a high prevalence of mutations among ARV-experienced children,whereas mutations were absent in the drug-naïve group. Despite the high levels of resistance among treatedinfants, an important improvement of their immunological status was observed. HIV-1 subtype distributionfollowed the trends of the adult population, with the appearance of non-B subtypes and recombinant formsafter 1990. To our knowledge, this is the largest pediatric cohort ever analyzed in Brazil, and the data providedis of paramount importance to a better understanding of HIV/AIDS evolution in pediatric settings. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776408 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.76 |
| format | Artículo científico |
| id | redalyc_32776408 |
| institution | Redalyc |
| language | en |
| publishDate | 2004 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil Elizabeth S. Machado Multidisciplinaria (Ciencias Naturales y Exactas) HIV subtype clinical pediatric genotyping Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil Elizabeth S. Machado John S. Lambert Adriana O. Afonso Silvia M. Cunha Ricardo H. Oliveira Amilcar Tanuri Anne M. Sill Marcelo A. Soares Multidisciplinaria (Ciencias Naturales y Exactas) HIV subtype clinical pediatric genotyping Although mother-to-child HIV transmission prevention has slowed down pediatric HIV infection in developedcountries, large numbers of infants still become infected in developing nations. Data on pediatric HIVinfection is however largely scarce. In this study, we have overviewed clinical, laboratory and genotypic datafrom a large cohort of HIV-infected infants regularly followed at two pediatric HIV outpatient clinics in Riode Janeiro, Brazil. Children on antiretroviral therapy, as well as drug-naïve, newly diagnosed infants wereanalyzed. Prevalence of drug resistance mutations, as well as immunological and virological responses totherapy were evaluated. Additionally, HIV-1 subtype frequencies and their distribution over the course of theepidemic were studied. We have found a high prevalence of mutations among ARV-experienced children,whereas mutations were absent in the drug-naïve group. Despite the high levels of resistance among treatedinfants, an important improvement of their immunological status was observed. HIV-1 subtype distributionfollowed the trends of the adult population, with the appearance of non-B subtypes and recombinant formsafter 1990. To our knowledge, this is the largest pediatric cohort ever analyzed in Brazil, and the data providedis of paramount importance to a better understanding of HIV/AIDS evolution in pediatric settings. 2004 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32776408 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.76 |
| title | Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) HIV subtype clinical pediatric genotyping |
| url | https://www.redalyc.org/articulo.oa?id=32776408 |