Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2005
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| _version_ | 1876429079658364928 |
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| author | Renato A. Mortara |
| author_facet | Renato A. Mortara |
| contents | Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms Renato A. Mortara Walter K. Andreoli Noemi N. Taniwaki Adriana B. Fernandes Claudio V. da Silva Maria Cecília D.C. Fernandes Carolina L'abbate Solange da Silva Multidisciplinaria (Ciencias Naturales y Exactas) cking amastigotes traffi trypomastigotes Trypanosomacruzi Trypanosomacruzi,theetiologicalagentofChagasdisease,occursasdifferentstrainsorisolatesthatmaybegroupedintwomajorphylogeneticlineages:T.cruziI,associatedwiththesylvaticcycleandT.cruziII,linkedtothehumandisease.Inthemammalianhosttheparasitehastoinvadecellsandmanystudiesimplicatedtheflagellatedtrypomastigotesinthisprocess.Severalparasitesurfacecomponentsandsomeofhostcellreceptorswithwhichtheyinteracthavebeenidentified.Ourworkfocusedonhowamastigotes,usuallyfoundgrowinginthecytoplasm,caninvademammaliancellswithinfectivitiescomparabletothatoftrypomastigotes.Wefounddifferencesincellularresponsesinducedbyamastigotesandtrypomastigotesregardingcytoskeletalcomponentsandactin-richprojections.ExtracellularlygeneratedamastigotesofT.cruziIstrainsmaydisplaygreaterinfectivitythanmetacyclictrypomastigotestowardsculturedcelllinesaswellastargetcellsthathavemodifiedexpressionofdifferentclassesofcellularcomponents.CulturedhostcellsharboringthebacteriumCoxiellaburnetiiallowedustogainnewinsightsintothetraffickingpropertiesofthedifferentinfectiveformsofT.cruzi,disclosingunexpectedrequirementsfortheparasitetotransitbetweentheparasitophorousvacuoletoitsfinaldestinationinthehostcellcytoplasm. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777106 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| format | Artículo científico |
| id | redalyc_32777106 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms Renato A. Mortara Multidisciplinaria (Ciencias Naturales y Exactas) cking amastigotes traffi trypomastigotes Trypanosomacruzi Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms Renato A. Mortara Walter K. Andreoli Noemi N. Taniwaki Adriana B. Fernandes Claudio V. da Silva Maria Cecília D.C. Fernandes Carolina L'abbate Solange da Silva Multidisciplinaria (Ciencias Naturales y Exactas) cking amastigotes traffi trypomastigotes Trypanosomacruzi Trypanosomacruzi,theetiologicalagentofChagasdisease,occursasdifferentstrainsorisolatesthatmaybegroupedintwomajorphylogeneticlineages:T.cruziI,associatedwiththesylvaticcycleandT.cruziII,linkedtothehumandisease.Inthemammalianhosttheparasitehastoinvadecellsandmanystudiesimplicatedtheflagellatedtrypomastigotesinthisprocess.Severalparasitesurfacecomponentsandsomeofhostcellreceptorswithwhichtheyinteracthavebeenidentified.Ourworkfocusedonhowamastigotes,usuallyfoundgrowinginthecytoplasm,caninvademammaliancellswithinfectivitiescomparabletothatoftrypomastigotes.Wefounddifferencesincellularresponsesinducedbyamastigotesandtrypomastigotesregardingcytoskeletalcomponentsandactin-richprojections.ExtracellularlygeneratedamastigotesofT.cruziIstrainsmaydisplaygreaterinfectivitythanmetacyclictrypomastigotestowardsculturedcelllinesaswellastargetcellsthathavemodifiedexpressionofdifferentclassesofcellularcomponents.CulturedhostcellsharboringthebacteriumCoxiellaburnetiiallowedustogainnewinsightsintothetraffickingpropertiesofthedifferentinfectiveformsofT.cruzi,disclosingunexpectedrequirementsfortheparasitetotransitbetweentheparasitophorousvacuoletoitsfinaldestinationinthehostcellcytoplasm. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777106 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| title | Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) cking amastigotes traffi trypomastigotes Trypanosomacruzi |
| url | https://www.redalyc.org/articulo.oa?id=32777106 |