A reassessment of the role of serotonergic system in the control of feeding behavior
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2005
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| _version_ | 1876446509036208128 |
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| author | Magda A. Medeiros |
| author_facet | Magda A. Medeiros |
| contents | A reassessment of the role of serotonergic system in the control of feeding behavior Magda A. Medeiros Ricardo H. Costa-e-Sousa Emerson L. Olivares Wellington S. Côrtes Luís C. Reis Multidisciplinaria (Ciencias Naturales y Exactas) para chloro obesity foodingestion phenylalanine Theroleofserotonergicsysteminthefeedingbehaviorwasappraisedbyelectrolyticlesionsinthedorsalraphenucleus(DRN)andadministrationofpara-chlorophenylalanine(PCPA,3mg/5µl,icv).Chronicevaluationswereaccomplishedthrough120and360daysinPCPA-injectedandDRN-lesionedrats,respectively.AcutefoodintakewasevaluatedinfastedratsandsubmittedtoinjectionofPCPAandhydroxytryptophan(LHTP,30mg/kg,ip).DRN-lesionedratsexhibited22-80%increaseinfoodintakeuptosixthmonth,whereastheobesitywasevidentandsustainedbywholeperiod.InPCPA-injectedratswasobservedaninitialincreaseinthefoodintakefollowedbyhypophagyfrom25thto30thdayandatransitoryincreaseofbodyweightfrom5thto60thday.Intheacutestudy,theLHTPrevertedpartiallythePCPA-inducedincreaseinfoodintakeoffastedratssuggestingasustainedcapacityofdecarboxylationofprecursorbyserotonergicneurons.SlowrestorationofthelevelsoffoodintakeinDRN-lesionedratsrevealsaneuroplasticityinthesystemsthatregulatefeedingbehavior.Aplateauonthebodyweightcurveinlesionedratspossiblyrepresentstheestablishmentofanewandhighersetpointofenergeticbalance. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777108 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| format | Artículo científico |
| id | redalyc_32777108 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | A reassessment of the role of serotonergic system in the control of feeding behavior Magda A. Medeiros Multidisciplinaria (Ciencias Naturales y Exactas) para chloro obesity foodingestion phenylalanine A reassessment of the role of serotonergic system in the control of feeding behavior Magda A. Medeiros Ricardo H. Costa-e-Sousa Emerson L. Olivares Wellington S. Côrtes Luís C. Reis Multidisciplinaria (Ciencias Naturales y Exactas) para chloro obesity foodingestion phenylalanine Theroleofserotonergicsysteminthefeedingbehaviorwasappraisedbyelectrolyticlesionsinthedorsalraphenucleus(DRN)andadministrationofpara-chlorophenylalanine(PCPA,3mg/5µl,icv).Chronicevaluationswereaccomplishedthrough120and360daysinPCPA-injectedandDRN-lesionedrats,respectively.AcutefoodintakewasevaluatedinfastedratsandsubmittedtoinjectionofPCPAandhydroxytryptophan(LHTP,30mg/kg,ip).DRN-lesionedratsexhibited22-80%increaseinfoodintakeuptosixthmonth,whereastheobesitywasevidentandsustainedbywholeperiod.InPCPA-injectedratswasobservedaninitialincreaseinthefoodintakefollowedbyhypophagyfrom25thto30thdayandatransitoryincreaseofbodyweightfrom5thto60thday.Intheacutestudy,theLHTPrevertedpartiallythePCPA-inducedincreaseinfoodintakeoffastedratssuggestingasustainedcapacityofdecarboxylationofprecursorbyserotonergicneurons.SlowrestorationofthelevelsoffoodintakeinDRN-lesionedratsrevealsaneuroplasticityinthesystemsthatregulatefeedingbehavior.Aplateauonthebodyweightcurveinlesionedratspossiblyrepresentstheestablishmentofanewandhighersetpointofenergeticbalance. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777108 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| title | A reassessment of the role of serotonergic system in the control of feeding behavior |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) para chloro obesity foodingestion phenylalanine |
| url | https://www.redalyc.org/articulo.oa?id=32777108 |