Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors
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| Format: | Artículo científico |
| Sprache: | en |
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Academia Brasileira de Ciências
2005
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| _version_ | 1876485955865542656 |
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| author | Luís C.S. Ferreira |
| author_facet | Luís C.S. Ferreira |
| contents | Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors Luís C.S. Ferreira Rita C.C. Ferreira Wolfgang Schumann Multidisciplinaria (Ciencias Naturales y Exactas) vaccines immunization Bacillussubtilis proteinexpression Bacillussubtilisandsomeofitscloserelativeshavealonghistoryofindustrialandbiotechnologicalapplica-tions.SearchforantigenexpressionsystemsbasedonrecombinantB.subtilisstrainssoundsattractivebothbytheextensivegeneticknowledgeandthelackofanoutermembrane,whichsimplifythesecretionandpu-rificationofheterologousproteins.Morerecently,geneticallymodifiedB.subtilissporeshavebeendescribedasindestructibledeliveryvehiclesforvaccineantigens.NonethelessbothproductionanddeliveryofantigensbyB.subtilisstrainsfacesomeinherentobstacles,asunstablegeneexpressionandreducedimmunogenicitythat,otherwise,canbeovercomebyalreadyavailablegenetechnologyapproaches.InthepresentreviewwepresentthestatusofB.subtilis-basedvaccineresearch,eitherasproteinfactoriesordeliveryvectors,anddiscusssomealternativesforabetteruseofgeneticallymodifiedstrains. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777109 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| format | Artículo científico |
| id | redalyc_32777109 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors Luís C.S. Ferreira Multidisciplinaria (Ciencias Naturales y Exactas) vaccines immunization Bacillussubtilis proteinexpression Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors Luís C.S. Ferreira Rita C.C. Ferreira Wolfgang Schumann Multidisciplinaria (Ciencias Naturales y Exactas) vaccines immunization Bacillussubtilis proteinexpression Bacillussubtilisandsomeofitscloserelativeshavealonghistoryofindustrialandbiotechnologicalapplica-tions.SearchforantigenexpressionsystemsbasedonrecombinantB.subtilisstrainssoundsattractivebothbytheextensivegeneticknowledgeandthelackofanoutermembrane,whichsimplifythesecretionandpu-rificationofheterologousproteins.Morerecently,geneticallymodifiedB.subtilissporeshavebeendescribedasindestructibledeliveryvehiclesforvaccineantigens.NonethelessbothproductionanddeliveryofantigensbyB.subtilisstrainsfacesomeinherentobstacles,asunstablegeneexpressionandreducedimmunogenicitythat,otherwise,canbeovercomebyalreadyavailablegenetechnologyapproaches.InthepresentreviewwepresentthestatusofB.subtilis-basedvaccineresearch,eitherasproteinfactoriesordeliveryvectors,anddiscusssomealternativesforabetteruseofgeneticallymodifiedstrains. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777109 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.77 |
| title | Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) vaccines immunization Bacillussubtilis proteinexpression |
| url | https://www.redalyc.org/articulo.oa?id=32777109 |