Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2005
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| _version_ | 1876487636453949440 |
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| author | Mabel B. Esteves |
| author_facet | Mabel B. Esteves |
| contents | Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes Mabel B. Esteves Ottília R. Affonso-Mitidieri Luis F. Marques-Santos Vivian M. Rumjanek Multidisciplinaria (Ciencias Naturales y Exactas) exosites serineproteases bloodcoagulation exogenousinhibitors Thehighspecificityofbloodcoagulationproteaseshasbeenattributednotonlytoresiduessurroundingtheactivesitebutalsotoothersurfacedomainsthatareinvolvedinrecognizingandinteractingwithmacromolec-ularsubstratesandinhibitors.Specificbloodcoagulationinhibitorsobtainedfromexogenoussourcessuchasbloodsuckingsalivaryglandsandsnakevenomshavebeenidentified.Someoftheseinhibitorsinteractwithexositesoncoagulationenzymes.Twoexamplesarediscussedinthisshortrevision.Bothrojaracinisasnakevenom-derivedproteinthatbindstothrombinexosites1and2.Complexformationimpairsseveralexosite-dependentactivitiesofthrombinincludingfibrinogencleavageandplateletactivation.Bothrojaracinalsointeractswithproexosite1onprothrombinthusdecreasingthezymogenactivationbytheprothrombi-nasecomplex(FXa/FVa).IxolarisisatwoKunitzticksalivaryglandinhibitor,thatishomologoustotissuefactorpathwayinhibitor.Recentlyitwasdemonstratedthatixolarisbindstoheparin-bindingexositeofFXa,thusimpairingtherecognitionofprothrombinbytheenzyme.Inaddition,ixolarisinteractswithFXpossiblythroughtheheparin-bindingproexosite.DifferentlyfromFX,theixolaris-FXcomplexisnotrecognizedassubstratebytheintrinsictenasecomplex(FIXa/FVIIIa).Weconcludethattheseinhibitorsmayserveastoolsforthestudyofcoagulationexositesaswellasprototypesfornewanticoagulantdrugs. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777208 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.77 |
| format | Artículo científico |
| id | redalyc_32777208 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes Mabel B. Esteves Multidisciplinaria (Ciencias Naturales y Exactas) exosites serineproteases bloodcoagulation exogenousinhibitors Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes Mabel B. Esteves Ottília R. Affonso-Mitidieri Luis F. Marques-Santos Vivian M. Rumjanek Multidisciplinaria (Ciencias Naturales y Exactas) exosites serineproteases bloodcoagulation exogenousinhibitors Thehighspecificityofbloodcoagulationproteaseshasbeenattributednotonlytoresiduessurroundingtheactivesitebutalsotoothersurfacedomainsthatareinvolvedinrecognizingandinteractingwithmacromolec-ularsubstratesandinhibitors.Specificbloodcoagulationinhibitorsobtainedfromexogenoussourcessuchasbloodsuckingsalivaryglandsandsnakevenomshavebeenidentified.Someoftheseinhibitorsinteractwithexositesoncoagulationenzymes.Twoexamplesarediscussedinthisshortrevision.Bothrojaracinisasnakevenom-derivedproteinthatbindstothrombinexosites1and2.Complexformationimpairsseveralexosite-dependentactivitiesofthrombinincludingfibrinogencleavageandplateletactivation.Bothrojaracinalsointeractswithproexosite1onprothrombinthusdecreasingthezymogenactivationbytheprothrombi-nasecomplex(FXa/FVa).IxolarisisatwoKunitzticksalivaryglandinhibitor,thatishomologoustotissuefactorpathwayinhibitor.Recentlyitwasdemonstratedthatixolarisbindstoheparin-bindingexositeofFXa,thusimpairingtherecognitionofprothrombinbytheenzyme.Inaddition,ixolarisinteractswithFXpossiblythroughtheheparin-bindingproexosite.DifferentlyfromFX,theixolaris-FXcomplexisnotrecognizedassubstratebytheintrinsictenasecomplex(FIXa/FVIIIa).Weconcludethattheseinhibitorsmayserveastoolsforthestudyofcoagulationexositesaswellasprototypesfornewanticoagulantdrugs. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777208 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.77 |
| title | Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) exosites serineproteases bloodcoagulation exogenousinhibitors |
| url | https://www.redalyc.org/articulo.oa?id=32777208 |