Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Academia Brasileira de Ciências
2005
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=32777209 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Vaccines based on the cell surface carbohydrates of pathogenic bacteria Christopher Jones Multidisciplinaria (Ciencias Naturales y Exactas) lipopolysaccharides GlycoconjugateVaccines Capsularpolysaccharides Glycoconjugatevaccines,inwhichacellsurfacecarbohydratefromamicro-organismiscovalentlyattachedtoanappropriatecarrierproteinareprovingtobethemosteffectivemeanstogenerateprotectiveimmuneresponsestopreventawiderangeofdiseases.Thetechnologyappearstobegenericandapplicabletoawiderangeofpathogens,aslongasantibodiesagainstsurfacecarbohydrateshelpprotectagainstinfection.Threesuchvaccines,againstHaemophilusinfluenzaetypeb,NeisseriameningitidisGroupCandsevenserotypesofStreptococcuspneumoniae,havealreadybeenlicensedandmanyothersareindevelopment.Thisarticlediscussestherationaleforthedevelopmentanduseofglycoconjugatevaccines,themechanismsbywhichtheyelicitTcell-dependentimmuneresponsesandtheimplicationsofthisforvaccinedevelopment,theroleofphysicochemicalmethodsinthecharacterisationandqualitycontrolofthesevaccines,andthenovelproductswhichareunderdevelopment. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777209 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.77