Does the panic attack activate the hypothalamic-pituitary-adrenal axis?
Fuente:
Redalyc
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Academia Brasileira de Ciências
2005
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1876459943298596864 |
|---|---|
| author | Cybele Garcia-Leal |
| author_facet | Cybele Garcia-Leal |
| contents | Does the panic attack activate the hypothalamic-pituitary-adrenal axis? Cybele Garcia-Leal Francisco S. Guimarães Frederico G. Graeff Cristina M. Del Ben Multidisciplinaria (Ciencias Naturales y Exactas) anxiety panic attack stress hormones A bibliographic search has been performed in MEDLINE using cortisol and panic as key-words, occurring inthe title and/or in the abstract. Human studies were selected, with no time limit. The following publicationswere excluded: reviewarticles, case reports, panic attacks in disorders other than panic disorder, and studies onchanges that occurred in-between panic attacks. The results showed that real-life panic attacks as well as thoseinduced by selective panicogenic agents such as lactate and carbon dioxide do not activate the hypothalamicpituitary-adrenal (HPA) axis. Agonists of the colecystokinin receptor B, such as the colecystokinin-4 peptideand pentagastrin, increase stress hormones regardless of the occurrence of a panic attack and thus, seem toactivate the HPA axis directly. The benzodiazepine antagonist flumazenil does not increase stress hormones,but this agent does not reliably induce panic attacks. Pharmacological agents that increased anxiety in bothnormal subjects and panic patients raised stress hormone levels; among them are the a2-adrenergic antagonistyohimbine, the serotonergic agents 1-(m-chlorophenyl) piperazine (mCPP) and fenfluramine, as well as thepsychostimulant agent caffeine. Therefore, the panic attack does not seem to activate the HPAaxis, in contrastto anticipatory anxiety. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777309 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.77 |
| format | Artículo científico |
| id | redalyc_32777309 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Does the panic attack activate the hypothalamic-pituitary-adrenal axis? Cybele Garcia-Leal Multidisciplinaria (Ciencias Naturales y Exactas) anxiety panic attack stress hormones Does the panic attack activate the hypothalamic-pituitary-adrenal axis? Cybele Garcia-Leal Francisco S. Guimarães Frederico G. Graeff Cristina M. Del Ben Multidisciplinaria (Ciencias Naturales y Exactas) anxiety panic attack stress hormones A bibliographic search has been performed in MEDLINE using cortisol and panic as key-words, occurring inthe title and/or in the abstract. Human studies were selected, with no time limit. The following publicationswere excluded: reviewarticles, case reports, panic attacks in disorders other than panic disorder, and studies onchanges that occurred in-between panic attacks. The results showed that real-life panic attacks as well as thoseinduced by selective panicogenic agents such as lactate and carbon dioxide do not activate the hypothalamicpituitary-adrenal (HPA) axis. Agonists of the colecystokinin receptor B, such as the colecystokinin-4 peptideand pentagastrin, increase stress hormones regardless of the occurrence of a panic attack and thus, seem toactivate the HPA axis directly. The benzodiazepine antagonist flumazenil does not increase stress hormones,but this agent does not reliably induce panic attacks. Pharmacological agents that increased anxiety in bothnormal subjects and panic patients raised stress hormone levels; among them are the a2-adrenergic antagonistyohimbine, the serotonergic agents 1-(m-chlorophenyl) piperazine (mCPP) and fenfluramine, as well as thepsychostimulant agent caffeine. Therefore, the panic attack does not seem to activate the HPAaxis, in contrastto anticipatory anxiety. 2005 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32777309 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.77 |
| title | Does the panic attack activate the hypothalamic-pituitary-adrenal axis? |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) anxiety panic attack stress hormones |
| url | https://www.redalyc.org/articulo.oa?id=32777309 |