Determinants of HIV-1 mother-to-child transmission in Southern Brazil
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Academia Brasileira de Ciências
2006
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| _version_ | 1876461553475125248 |
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| author | Esmeralda A. J.M. Soares |
| author_facet | Esmeralda A. J.M. Soares |
| contents | Determinants of HIV-1 mother-to-child transmission in Southern Brazil Esmeralda A. J.M. Soares Ana M. B. Martínez Vanusa P. da Hora Raul Mendoza-Sassi Andréa Von Groll Nildo D'Avila Jussara Silveira Renata G. Leal Hu- Furg Adriana L. dos Santos Amilcar Tanuri Marcelo A. Soares Multidisciplinaria (Ciencias Naturales y Exactas) HIV MTCT subtype C vertical transmission molecular epidemiology Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunologicaland pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among thoseproperties, but few and controversial results have been described so far. In this study, 102 children bornfrom HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed forpotential risk factors associated with MTCT. That geographic region is characterized by a high proportionof subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence onMTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regressionanalyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR)and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C ofover 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT.HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although aclear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increased riskof vertical transmission. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778111 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.78 |
| format | Artículo científico |
| id | redalyc_32778111 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Determinants of HIV-1 mother-to-child transmission in Southern Brazil Esmeralda A. J.M. Soares Multidisciplinaria (Ciencias Naturales y Exactas) HIV MTCT subtype C vertical transmission molecular epidemiology Determinants of HIV-1 mother-to-child transmission in Southern Brazil Esmeralda A. J.M. Soares Ana M. B. Martínez Vanusa P. da Hora Raul Mendoza-Sassi Andréa Von Groll Nildo D'Avila Jussara Silveira Renata G. Leal Hu- Furg Adriana L. dos Santos Amilcar Tanuri Marcelo A. Soares Multidisciplinaria (Ciencias Naturales y Exactas) HIV MTCT subtype C vertical transmission molecular epidemiology Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunologicaland pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among thoseproperties, but few and controversial results have been described so far. In this study, 102 children bornfrom HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed forpotential risk factors associated with MTCT. That geographic region is characterized by a high proportionof subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence onMTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regressionanalyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR)and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C ofover 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT.HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although aclear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increased riskof vertical transmission. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778111 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.78 |
| title | Determinants of HIV-1 mother-to-child transmission in Southern Brazil |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) HIV MTCT subtype C vertical transmission molecular epidemiology |
| url | https://www.redalyc.org/articulo.oa?id=32778111 |