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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2006
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32778309 |
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| author | Patricia Chakur Brum |
| author_facet | Patricia Chakur Brum |
| contents | Neurohumoral activation in heart failure: the role of adrenergic receptors Patricia Chakur Brum Natale P. L. Rolim Aline V. N. Bacurau Alessandra Medeiros Multidisciplinaria (Ciencias Naturales y Exactas) heart failure adrenergic receptors sympathetic nervous system Heart failure (HF) is a common endpoint for many forms of cardiovascular disease and a significant cause ofmorbidity and mortality. The development of end-stage HF often involves an initial insult to the myocardiumthat reduces cardiac output and leads to a compensatory increase in sympathetic nervous system activity.Acutely, the sympathetic hyperactivity through the activation of beta-adrenergic receptors increases heartrate and cardiac contractility, which compensate for decreased cardiac output. However, chronic exposure ofthe heart to elevated levels of catecholamines released from sympathetic nerve terminals and the adrenal glandmay lead to further pathologic changes in the heart, resulting in continued elevation of sympathetic tone and aprogressive deterioration in cardiac function. On a molecular level, altered beta-adrenergic receptor signalingplays a pivotal role in the genesis and progression of HF. beta-adrenergic receptor number and function aredecreased, and downstream mechanisms are altered. In this review we will present an overview of the normalbeta-adrenergic receptor pathway in the heart and the consequences of sustained adrenergic activation in HF.The myopathic potential of individual components of the adrenergic signaling will be discussed through theresults of research performed in genetic modified animals. Finally, we will discuss the potential clinicalimpact of beta-adrenergic receptor gene polymorphisms for better understanding the progression of HF. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778309 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.78 |
| format | Artículo científico |
| id | redalyc_32778309 |
| language | en |
| publishDate | 2006 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Neurohumoral activation in heart failure: the role of adrenergic receptors Patricia Chakur Brum Multidisciplinaria (Ciencias Naturales y Exactas) heart failure adrenergic receptors sympathetic nervous system Neurohumoral activation in heart failure: the role of adrenergic receptors Patricia Chakur Brum Natale P. L. Rolim Aline V. N. Bacurau Alessandra Medeiros Multidisciplinaria (Ciencias Naturales y Exactas) heart failure adrenergic receptors sympathetic nervous system Heart failure (HF) is a common endpoint for many forms of cardiovascular disease and a significant cause ofmorbidity and mortality. The development of end-stage HF often involves an initial insult to the myocardiumthat reduces cardiac output and leads to a compensatory increase in sympathetic nervous system activity.Acutely, the sympathetic hyperactivity through the activation of beta-adrenergic receptors increases heartrate and cardiac contractility, which compensate for decreased cardiac output. However, chronic exposure ofthe heart to elevated levels of catecholamines released from sympathetic nerve terminals and the adrenal glandmay lead to further pathologic changes in the heart, resulting in continued elevation of sympathetic tone and aprogressive deterioration in cardiac function. On a molecular level, altered beta-adrenergic receptor signalingplays a pivotal role in the genesis and progression of HF. beta-adrenergic receptor number and function aredecreased, and downstream mechanisms are altered. In this review we will present an overview of the normalbeta-adrenergic receptor pathway in the heart and the consequences of sustained adrenergic activation in HF.The myopathic potential of individual components of the adrenergic signaling will be discussed through theresults of research performed in genetic modified animals. Finally, we will discuss the potential clinicalimpact of beta-adrenergic receptor gene polymorphisms for better understanding the progression of HF. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778309 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.78 |
| title | Neurohumoral activation in heart failure: the role of adrenergic receptors |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) heart failure adrenergic receptors sympathetic nervous system |
| url | https://www.redalyc.org/articulo.oa?id=32778309 |