The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function
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Academia Brasileira de Ciências
2006
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| _version_ | 1876425568826687488 |
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| author | Marta H. Branquinha |
| author_facet | Marta H. Branquinha |
| contents | The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function Marta H. Branquinha Claudia M. D'Avila-Levy André L. S. Santos Multidisciplinaria (Ciencias Naturales y Exactas) gp63 adhesion protease nutrition Trypanosomatidae Plant and insect trypanosomatids constitute the lower trypanosomatids, which have been used routinely aslaboratory models for biochemical and molecular studies because they are easily cultured under axenic conditions,and they contain homologues of virulence factors from the classic human trypanosomatid pathogens.Among the molecular factors that contribute to Leishmania spp. virulence and pathogenesis, the major surfaceprotease, alternatively called MSP, PSP, leishmanolysin, EC 3.4.24.36 and gp63, is the most abundantsurface protein of leishmania promastigotes. A myriad of functions have been described for the gp63 fromLeishmania spp. when the metacyclic promastigote is inside the mammalian host. However, less is knownabout the functions performed by this molecule in the invertebrate vector. Intriguingly, gp63 is predominantlyexpressed in the insect stage of Leishmania, and in all insect and plant trypanosomatids examined so far.The gp63 homologues found in lower trypanosomatids seem to play essential roles in the nutrition as wellas in the interaction with the insect epithelial cells. Since excellent reviews were produced in the last decaderegarding the roles played by proteases in the vertebrate hosts, we focused in the recent developments in ourunderstanding of the biochemistry and cell biology of gp63-like proteins in lower trypanosomatids. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778406 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.78 |
| format | Artículo científico |
| id | redalyc_32778406 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function Marta H. Branquinha Multidisciplinaria (Ciencias Naturales y Exactas) gp63 adhesion protease nutrition Trypanosomatidae The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function Marta H. Branquinha Claudia M. D'Avila-Levy André L. S. Santos Multidisciplinaria (Ciencias Naturales y Exactas) gp63 adhesion protease nutrition Trypanosomatidae Plant and insect trypanosomatids constitute the lower trypanosomatids, which have been used routinely aslaboratory models for biochemical and molecular studies because they are easily cultured under axenic conditions,and they contain homologues of virulence factors from the classic human trypanosomatid pathogens.Among the molecular factors that contribute to Leishmania spp. virulence and pathogenesis, the major surfaceprotease, alternatively called MSP, PSP, leishmanolysin, EC 3.4.24.36 and gp63, is the most abundantsurface protein of leishmania promastigotes. A myriad of functions have been described for the gp63 fromLeishmania spp. when the metacyclic promastigote is inside the mammalian host. However, less is knownabout the functions performed by this molecule in the invertebrate vector. Intriguingly, gp63 is predominantlyexpressed in the insect stage of Leishmania, and in all insect and plant trypanosomatids examined so far.The gp63 homologues found in lower trypanosomatids seem to play essential roles in the nutrition as wellas in the interaction with the insect epithelial cells. Since excellent reviews were produced in the last decaderegarding the roles played by proteases in the vertebrate hosts, we focused in the recent developments in ourunderstanding of the biochemistry and cell biology of gp63-like proteins in lower trypanosomatids. 2006 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32778406 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.78 |
| title | The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) gp63 adhesion protease nutrition Trypanosomatidae |
| url | https://www.redalyc.org/articulo.oa?id=32778406 |