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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2007
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32779209 |
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| _version_ | 1866556991628902400 |
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| author | Luís C. Reis |
| author_facet | Luís C. Reis |
| contents | Role of the serotoninergic system in the sodium appetite control Luís C. Reis Multidisciplinaria (Ciencias Naturales y Exactas) HTergic system HTergic agents sodium appetite dorsal raphe nucleus hydroelectrolyte balance The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from theperipheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors inthe modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonindepletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brainserotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodiumdepletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesisthat the suppression of ascending pathways from the DRN, possibly, 5-HTergic fibers, modifies the angiotensinergicor sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergicblockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked byvolume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. Inconclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRNand LPBN, for the sodium appetite control 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779209 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779209 |
| language | en |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Role of the serotoninergic system in the sodium appetite control Luís C. Reis Multidisciplinaria (Ciencias Naturales y Exactas) HTergic system HTergic agents sodium appetite dorsal raphe nucleus hydroelectrolyte balance Role of the serotoninergic system in the sodium appetite control Luís C. Reis Multidisciplinaria (Ciencias Naturales y Exactas) HTergic system HTergic agents sodium appetite dorsal raphe nucleus hydroelectrolyte balance The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from theperipheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors inthe modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonindepletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brainserotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodiumdepletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesisthat the suppression of ascending pathways from the DRN, possibly, 5-HTergic fibers, modifies the angiotensinergicor sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergicblockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked byvolume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. Inconclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRNand LPBN, for the sodium appetite control 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779209 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.79 |
| title | Role of the serotoninergic system in the sodium appetite control |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) HTergic system HTergic agents sodium appetite dorsal raphe nucleus hydroelectrolyte balance |
| url | https://www.redalyc.org/articulo.oa?id=32779209 |