The extracellular matrix of the lung and its role in edema formation
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2007
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| _version_ | 1876461569139802112 |
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| author | Paolo Pelosi |
| author_facet | Paolo Pelosi |
| contents | The extracellular matrix of the lung and its role in edema formation Paolo Pelosi Patricia R.M. Rocco Daniela Negrini Alberto Passi Multidisciplinaria (Ciencias Naturales y Exactas) collagen proteoglycan glycosaminoglycans interstitial pressure The extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as:collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrixhas several functions which provide: 1) mechanical tensile and compressive strength and elasticity, 2) low mechanicaltissue compliance contributing to the maintenance of normal interstitial fluid dynamics, 3) low resistive pathway foran effective gas exchange, d) control of cell behavior by the binding of growth factors, chemokines, cytokines andthe interaction with cell-surface receptors, and e) tissue repair and remodeling. Fragmentation and disorganization ofextracellular matrix components comprises the protective role of the extracellular matrix, leading to interstitial andeventually severe lung edema. Thus, once conditions of increased microvascular filtration are established, matrixremodeling proceeds fairly rapidly due to the activation of proteases. Conversely, a massive matrix deposition ofcollagen fiber decreases interstitial compliance and therefore makes the tissue safety factor stronger. As a result,changes in lung extracellular matrix significantly affect edema formation and distribution in the lung 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779210 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779210 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The extracellular matrix of the lung and its role in edema formation Paolo Pelosi Multidisciplinaria (Ciencias Naturales y Exactas) collagen proteoglycan glycosaminoglycans interstitial pressure The extracellular matrix of the lung and its role in edema formation Paolo Pelosi Patricia R.M. Rocco Daniela Negrini Alberto Passi Multidisciplinaria (Ciencias Naturales y Exactas) collagen proteoglycan glycosaminoglycans interstitial pressure The extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as:collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrixhas several functions which provide: 1) mechanical tensile and compressive strength and elasticity, 2) low mechanicaltissue compliance contributing to the maintenance of normal interstitial fluid dynamics, 3) low resistive pathway foran effective gas exchange, d) control of cell behavior by the binding of growth factors, chemokines, cytokines andthe interaction with cell-surface receptors, and e) tissue repair and remodeling. Fragmentation and disorganization ofextracellular matrix components comprises the protective role of the extracellular matrix, leading to interstitial andeventually severe lung edema. Thus, once conditions of increased microvascular filtration are established, matrixremodeling proceeds fairly rapidly due to the activation of proteases. Conversely, a massive matrix deposition ofcollagen fiber decreases interstitial compliance and therefore makes the tissue safety factor stronger. As a result,changes in lung extracellular matrix significantly affect edema formation and distribution in the lung 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779210 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.2 Vol.79 |
| title | The extracellular matrix of the lung and its role in edema formation |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) collagen proteoglycan glycosaminoglycans interstitial pressure |
| url | https://www.redalyc.org/articulo.oa?id=32779210 |