The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea
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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2007
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| author | Luiz Felipe de Moraes Barros |
| author_facet | Luiz Felipe de Moraes Barros |
| contents | The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea Luiz Felipe de Moraes Barros Rubens Belfort Multidisciplinaria (Ciencias Naturales y Exactas) cornea bevacizumab angiogenesis neovascularization The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of bevacizumab(Avastin) on angiogenesis in the rat cornea. Corneas of 20Wistar male rats were cauterized with silver nitrate crystal.Animals were divided in four groups: control group (GC) that received subconjunctivally 0.02 ml of 0.9% salinesolution on the day of the lesion; group GO that received subconjunctivally 0.02 ml of bevacizumab just after the lesion;group G3 that received bevacizumab on day 3 and group G5 that received bevacizumab on day 5 after lesion. Animalswere euthanized on day 7. The newly formed vessels were quantified after China Ink perfusion and photographs wereobtained and analyzed in a computerized system (Image Pro-Plus). In the control group, neovascularization covered53.56% ± 15.11 (mean ± SD) of the corneal surface, compared with 35.57% ± 18.80 (mean ± SD) in the G0 group,30.60%±11.82 (mean±SD) in the G3 and 35.86%±0.07 (mean±SD) in the G5. The results showed an inhibition ofangiogenesis when the control group was compared with all treated groups. These results suggest that subconjunctivalinjection of bevacizumab is able to inhibit corneal angiogenesis independently of the day of treatment. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779304 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779304 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea Luiz Felipe de Moraes Barros Multidisciplinaria (Ciencias Naturales y Exactas) cornea bevacizumab angiogenesis neovascularization The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea Luiz Felipe de Moraes Barros Rubens Belfort Multidisciplinaria (Ciencias Naturales y Exactas) cornea bevacizumab angiogenesis neovascularization The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of bevacizumab(Avastin) on angiogenesis in the rat cornea. Corneas of 20Wistar male rats were cauterized with silver nitrate crystal.Animals were divided in four groups: control group (GC) that received subconjunctivally 0.02 ml of 0.9% salinesolution on the day of the lesion; group GO that received subconjunctivally 0.02 ml of bevacizumab just after the lesion;group G3 that received bevacizumab on day 3 and group G5 that received bevacizumab on day 5 after lesion. Animalswere euthanized on day 7. The newly formed vessels were quantified after China Ink perfusion and photographs wereobtained and analyzed in a computerized system (Image Pro-Plus). In the control group, neovascularization covered53.56% ± 15.11 (mean ± SD) of the corneal surface, compared with 35.57% ± 18.80 (mean ± SD) in the G0 group,30.60%±11.82 (mean±SD) in the G3 and 35.86%±0.07 (mean±SD) in the G5. The results showed an inhibition ofangiogenesis when the control group was compared with all treated groups. These results suggest that subconjunctivalinjection of bevacizumab is able to inhibit corneal angiogenesis independently of the day of treatment. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779304 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.3 Vol.79 |
| title | The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) cornea bevacizumab angiogenesis neovascularization |
| url | https://www.redalyc.org/articulo.oa?id=32779304 |