Antifungal activity of the extracts and saponins from Sapindus saponaria L.
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| Format: | Artículo científico |
| Langue: | en |
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Academia Brasileira de Ciências
2007
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| _version_ | 1876462045809868800 |
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| author | Joyce K. Tsuzuki |
| author_facet | Joyce K. Tsuzuki |
| contents | Antifungal activity of the extracts and saponins from Sapindus saponaria L. Joyce K. Tsuzuki Terezinha I.E. Svidzinski Cristiane S. Shinobu Luiz F.A. Silva Edson Rodrigues Diógenes A.G. Cortez Izabel C.P. Ferreira Multidisciplinaria (Ciencias Naturales y Exactas) Candida saponins Sapindaceae Sapindus saponaria antifungal activity Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungalactivity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women withVulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis,C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extractwas bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extractand one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separationof this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-β-D-xylopyranosyl)-(1→3)-α-Lrhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-β-D-xylopyranosyl)-(1→3)-α-L-rhamnopyranosyl-(1→2)-α- L-arabynopyranosyl-hederagenin (2). The structures of the compounds were basedon spectral data (1H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showedstrong activity against C. parapsilosis. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779402 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779402 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Antifungal activity of the extracts and saponins from Sapindus saponaria L. Joyce K. Tsuzuki Multidisciplinaria (Ciencias Naturales y Exactas) Candida saponins Sapindaceae Sapindus saponaria antifungal activity Antifungal activity of the extracts and saponins from Sapindus saponaria L. Joyce K. Tsuzuki Terezinha I.E. Svidzinski Cristiane S. Shinobu Luiz F.A. Silva Edson Rodrigues Diógenes A.G. Cortez Izabel C.P. Ferreira Multidisciplinaria (Ciencias Naturales y Exactas) Candida saponins Sapindaceae Sapindus saponaria antifungal activity Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungalactivity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women withVulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis,C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extractwas bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extractand one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separationof this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-β-D-xylopyranosyl)-(1→3)-α-Lrhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-β-D-xylopyranosyl)-(1→3)-α-L-rhamnopyranosyl-(1→2)-α- L-arabynopyranosyl-hederagenin (2). The structures of the compounds were basedon spectral data (1H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showedstrong activity against C. parapsilosis. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779402 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| title | Antifungal activity of the extracts and saponins from Sapindus saponaria L. |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Candida saponins Sapindaceae Sapindus saponaria antifungal activity |
| url | https://www.redalyc.org/articulo.oa?id=32779402 |