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| Format: | Artículo científico |
| Language: | en |
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Academia Brasileira de Ciências
2007
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| Online Access: | https://www.redalyc.org/articulo.oa?id=32779404 |
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| author | Paula A. Oliveira |
| author_facet | Paula A. Oliveira |
| contents | Chemical carcinogenesis Paula A. Oliveira Aura Colaço Raquel Chaves Henrique Guedes-Pinto Luis F. de-la-Cruz P. Carlos Lopes Multidisciplinaria (Ciencias Naturales y Exactas) cancer stages chemical carcinogens chemical carcinogenesis carcinogenesis evaluation The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs tobe produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increasein levels of life expectancy. Yet, at times, these benefits are offset by certain disadvantages, notably the toxic sideeffects of the chemical compounds used. Exposure to these compounds can have varying effects, ranging from instantdeath to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis.These are defined as initiation, promotion and progression. Each of these stages is characterised by morphological andbiochemical modifications and result from genetic and/or epigenetic alterations. These genetic modifications include:mutations in genes that control cell proliferation, cell death and DNA repair i.e. mutations in proto-oncogenesand tumour suppressing genes. The epigenetic factors, also considered as being non-genetic in character, can alsocontribute to carcinogenesis via epigenetic mechanisms which silence gene expression. The control of responsesto carcinogenesis through the application of several chemical, biochemical and biological techniques facilitates theidentification of those basic mechanisms involved in neoplasic development. Experimental assays with laboratoryanimals, epidemiological studies and quick tests enable the identification of carcinogenic compounds, the dissection ofmany aspects of carcinogenesis, and the establishment of effective strategies to prevent the cancer which results fromexposure to chemicals. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779404 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779404 |
| language | en |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Chemical carcinogenesis Paula A. Oliveira Multidisciplinaria (Ciencias Naturales y Exactas) cancer stages chemical carcinogens chemical carcinogenesis carcinogenesis evaluation Chemical carcinogenesis Paula A. Oliveira Aura Colaço Raquel Chaves Henrique Guedes-Pinto Luis F. de-la-Cruz P. Carlos Lopes Multidisciplinaria (Ciencias Naturales y Exactas) cancer stages chemical carcinogens chemical carcinogenesis carcinogenesis evaluation The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs tobe produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increasein levels of life expectancy. Yet, at times, these benefits are offset by certain disadvantages, notably the toxic sideeffects of the chemical compounds used. Exposure to these compounds can have varying effects, ranging from instantdeath to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis.These are defined as initiation, promotion and progression. Each of these stages is characterised by morphological andbiochemical modifications and result from genetic and/or epigenetic alterations. These genetic modifications include:mutations in genes that control cell proliferation, cell death and DNA repair i.e. mutations in proto-oncogenesand tumour suppressing genes. The epigenetic factors, also considered as being non-genetic in character, can alsocontribute to carcinogenesis via epigenetic mechanisms which silence gene expression. The control of responsesto carcinogenesis through the application of several chemical, biochemical and biological techniques facilitates theidentification of those basic mechanisms involved in neoplasic development. Experimental assays with laboratoryanimals, epidemiological studies and quick tests enable the identification of carcinogenic compounds, the dissection ofmany aspects of carcinogenesis, and the establishment of effective strategies to prevent the cancer which results fromexposure to chemicals. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779404 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| title | Chemical carcinogenesis |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) cancer stages chemical carcinogens chemical carcinogenesis carcinogenesis evaluation |
| url | https://www.redalyc.org/articulo.oa?id=32779404 |