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| Natura: | Artículo científico |
| Lingua: | pt |
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Academia Brasileira de Ciências
2007
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=32779405 |
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| _version_ | 1866812397158662144 |
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| author | Nicolas Wiernsperger |
| author_facet | Nicolas Wiernsperger |
| contents | Microcirculation in obesity: an unexplored domain Nicolas Wiernsperger Pierre Nivoit Eliete Bouskela Multidisciplinaria (Ciencias Naturales y Exactas) leptin leptina birth weight peso ao nascer diabetes mellitus Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological,sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution offat is the important determinant. Moderate abdominal fat accumulation may thus be more harmful than even consequentoverweight. In view of the worldwide burden of obesity, factors leading to it in children and young adults must urgentlybe identified. Since obesity is a very complex cardiometabolic situation, this will require to focus investigations onuncomplicated obese subjects and adequate animal models. The recent discovery of intergenerational transmissionsof obesity risk factors and also the key role played by gestational and perinatal events (epigenetic factors) give rise tocompletely new concepts and research avenues. Considering the potential close relationship between microcirculationand tissue metabolism, demonstrations of structural and/or functional abnormalities in microvascular physiology veryearly in life of subjects at risk for obesity might provide a solid basis for further investigations of such links. Microcirculation(arterioles, capillaries and venules) is conceivably a key compartment determining over one or several decadesthe translation of genetic and epigenetic factors into fat accumulation. Available animal models should serve to answerthis cardinal question. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779405 pt http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| format | Artículo científico |
| id | redalyc_32779405 |
| language | pt |
| publishDate | 2007 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | Microcirculation in obesity: an unexplored domain Nicolas Wiernsperger Multidisciplinaria (Ciencias Naturales y Exactas) leptin leptina birth weight peso ao nascer diabetes mellitus Microcirculation in obesity: an unexplored domain Nicolas Wiernsperger Pierre Nivoit Eliete Bouskela Multidisciplinaria (Ciencias Naturales y Exactas) leptin leptina birth weight peso ao nascer diabetes mellitus Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological,sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution offat is the important determinant. Moderate abdominal fat accumulation may thus be more harmful than even consequentoverweight. In view of the worldwide burden of obesity, factors leading to it in children and young adults must urgentlybe identified. Since obesity is a very complex cardiometabolic situation, this will require to focus investigations onuncomplicated obese subjects and adequate animal models. The recent discovery of intergenerational transmissionsof obesity risk factors and also the key role played by gestational and perinatal events (epigenetic factors) give rise tocompletely new concepts and research avenues. Considering the potential close relationship between microcirculationand tissue metabolism, demonstrations of structural and/or functional abnormalities in microvascular physiology veryearly in life of subjects at risk for obesity might provide a solid basis for further investigations of such links. Microcirculation(arterioles, capillaries and venules) is conceivably a key compartment determining over one or several decadesthe translation of genetic and epigenetic factors into fat accumulation. Available animal models should serve to answerthis cardinal question. 2007 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32779405 pt http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.4 Vol.79 |
| title | Microcirculation in obesity: an unexplored domain |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) leptin leptina birth weight peso ao nascer diabetes mellitus |
| url | https://www.redalyc.org/articulo.oa?id=32779405 |