The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2008
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| _version_ | 1876437380218486784 |
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| author | Marianne G. Resende |
| author_facet | Marianne G. Resende |
| contents | The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain Marianne G. Resende Blima Fux Bráulia C. Caetano Erica A. Mendes Ricardo T. Gazzinelli Adriana M. Ferreira Maria Norma Melo Ricardo W. A. Vitor Neide M. Silva Multidisciplinaria (Ciencias Naturales y Exactas) TLR and MHC innate immunity acquired immunity Toxoplasma gondii strains Toxoplasma gondii strains displaying the Type I/III genotype are associated with acquired ocular toxoplasmosis inhumans. Here, we used a mice model to characterize some immunological mechanisms involved in host resistance toinfection with such strains. We have chosen the Type I/III strains D8, G2 and P-Br, which cause a chronic infectionin mice that resembles human toxoplamosis. Mice deficient of molecules MyD88, IFN-γ , and IL-12 were susceptibleto all three parasite strains. This finding indicates the importance of innate mechanisms in controlling infection. Onthe other hand, MHC haplotype did not influenced resistance/susceptibility; since mice lineages displaying a samegenetic background but different MHC haplotypes (H2b or H2d) developed similar mortality and cyst numbers afterinfection with those strains. In contrast, the C57BL/6 genetic background, and not MHC haplotype, was critical fordevelopment of intestinal inflammation caused by any of the studied strains. Finally, regarding effector mechanisms,we observed that B and CD8+ T lymphocytes controlled survival, whereas the inducible nitric oxide synthase influencedcyst numbers in brains of mice infected with Type I/III strains. These findings are relevant to further understanding ofthe immunologic mechanisms involved in host protection and pathogenesis during infection with T. gondii. 2008 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32780105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.80 |
| format | Artículo científico |
| id | redalyc_32780105 |
| institution | Redalyc |
| language | en |
| publishDate | 2008 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain Marianne G. Resende Multidisciplinaria (Ciencias Naturales y Exactas) TLR and MHC innate immunity acquired immunity Toxoplasma gondii strains The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain Marianne G. Resende Blima Fux Bráulia C. Caetano Erica A. Mendes Ricardo T. Gazzinelli Adriana M. Ferreira Maria Norma Melo Ricardo W. A. Vitor Neide M. Silva Multidisciplinaria (Ciencias Naturales y Exactas) TLR and MHC innate immunity acquired immunity Toxoplasma gondii strains Toxoplasma gondii strains displaying the Type I/III genotype are associated with acquired ocular toxoplasmosis inhumans. Here, we used a mice model to characterize some immunological mechanisms involved in host resistance toinfection with such strains. We have chosen the Type I/III strains D8, G2 and P-Br, which cause a chronic infectionin mice that resembles human toxoplamosis. Mice deficient of molecules MyD88, IFN-γ , and IL-12 were susceptibleto all three parasite strains. This finding indicates the importance of innate mechanisms in controlling infection. Onthe other hand, MHC haplotype did not influenced resistance/susceptibility; since mice lineages displaying a samegenetic background but different MHC haplotypes (H2b or H2d) developed similar mortality and cyst numbers afterinfection with those strains. In contrast, the C57BL/6 genetic background, and not MHC haplotype, was critical fordevelopment of intestinal inflammation caused by any of the studied strains. Finally, regarding effector mechanisms,we observed that B and CD8+ T lymphocytes controlled survival, whereas the inducible nitric oxide synthase influencedcyst numbers in brains of mice infected with Type I/III strains. These findings are relevant to further understanding ofthe immunologic mechanisms involved in host protection and pathogenesis during infection with T. gondii. 2008 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32780105 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.80 |
| title | The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) TLR and MHC innate immunity acquired immunity Toxoplasma gondii strains |
| url | https://www.redalyc.org/articulo.oa?id=32780105 |