COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C>T in its "frizzled" motif is associated with obesity in diabetes type 2 patients
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| Natura: | Artículo científico |
| Lingua: | en |
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Academia Brasileira de Ciências
2008
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| _version_ | 1876433053766647808 |
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| author | Maria Rita Passos-Bueno |
| author_facet | Maria Rita Passos-Bueno |
| contents | COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C>T in its "frizzled" motif is associated with obesity in diabetes type 2 patients Maria Rita Passos-Bueno Oscar T. Suzuki Andréa L. Sertié Flavia I. V. Errera Erika Yeh Érika Kague Lucia M. Armelin-Corrêa Luís H. Canani Balduíno Tschiedel Maria Elizabeth R. Silva Multidisciplinaria (Ciencias Naturales y Exactas) COL18A1 obesity frizzled endostatin adipogenesis Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signalingand Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII andWnt signaling have recently been associated with adipogenic differentiation and obesity in some animal models, butnot in humans. In the present report, we have shown that COL18A1 expression increases during human adipogenic differentiation.We also tested if polymorphisms in the Frizzled (c.1136C>T; Thr379Met) and Endostatin (c.4349G>A;Asp1437Asn) regions contribute towards susceptibility to obesity in patients with type 2 diabetes (113 obese, BMI≥30; 232 non-obese, BMI < 30) of European ancestry. No evidence of association was observed between the allelec.4349G>A and obesity, but we observed a significantly higher frequency of homozygotes c.1136TT in obese (19.5%)than in non-obese individuals (10.9%) [P = 0.02; OR = 2.0 (95%CI: 1.07-3.73)], suggesting that the allele c.1136Tis associated to obesity in a recessive model. This genotype, after controlling for cholesterol, LDL cholesterol, andtriglycerides, was independently associated with obesity (P = 0.048), and increases the chance of obesity in 2.8 times.Therefore, our data suggest the involvement of collagen XVIII in human adipogenesis and susceptibility to obesity. 2008 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32780112 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.80 |
| format | Artículo científico |
| id | redalyc_32780112 |
| institution | Redalyc |
| language | en |
| publishDate | 2008 |
| publisher | Academia Brasileira de Ciências |
| spellingShingle | COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C>T in its "frizzled" motif is associated with obesity in diabetes type 2 patients Maria Rita Passos-Bueno Multidisciplinaria (Ciencias Naturales y Exactas) COL18A1 obesity frizzled endostatin adipogenesis COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C>T in its "frizzled" motif is associated with obesity in diabetes type 2 patients Maria Rita Passos-Bueno Oscar T. Suzuki Andréa L. Sertié Flavia I. V. Errera Erika Yeh Érika Kague Lucia M. Armelin-Corrêa Luís H. Canani Balduíno Tschiedel Maria Elizabeth R. Silva Multidisciplinaria (Ciencias Naturales y Exactas) COL18A1 obesity frizzled endostatin adipogenesis Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signalingand Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII andWnt signaling have recently been associated with adipogenic differentiation and obesity in some animal models, butnot in humans. In the present report, we have shown that COL18A1 expression increases during human adipogenic differentiation.We also tested if polymorphisms in the Frizzled (c.1136C>T; Thr379Met) and Endostatin (c.4349G>A;Asp1437Asn) regions contribute towards susceptibility to obesity in patients with type 2 diabetes (113 obese, BMI≥30; 232 non-obese, BMI < 30) of European ancestry. No evidence of association was observed between the allelec.4349G>A and obesity, but we observed a significantly higher frequency of homozygotes c.1136TT in obese (19.5%)than in non-obese individuals (10.9%) [P = 0.02; OR = 2.0 (95%CI: 1.07-3.73)], suggesting that the allele c.1136Tis associated to obesity in a recessive model. This genotype, after controlling for cholesterol, LDL cholesterol, andtriglycerides, was independently associated with obesity (P = 0.048), and increases the chance of obesity in 2.8 times.Therefore, our data suggest the involvement of collagen XVIII in human adipogenesis and susceptibility to obesity. 2008 artículo científico 0001-3765 https://www.redalyc.org/articulo.oa?id=32780112 en http://www.redalyc.org/revista.oa?id=327 Anais da Academia Brasileira de Ciências application/pdf Academia Brasileira de Ciências Anais da Academia Brasileira de Ciências (Brasil) Num.1 Vol.80 |
| title | COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C>T in its "frizzled" motif is associated with obesity in diabetes type 2 patients |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) COL18A1 obesity frizzled endostatin adipogenesis |
| url | https://www.redalyc.org/articulo.oa?id=32780112 |